Progesterone receptor (PR) is a master regulator in female reproductive tissues that controls
developmental processes and proliferation and differentiation during the reproductive cycle …

While the structures of the DNA-and ligand-binding domains of many nuclear receptors have
been determined in great detail; the mechanisms by which these domains interact and …

Therapeutic targeting of nuclear receptors (NRs) is presently restricted due to 2 constraints:
1) a limited knowledge of the structural dynamics of intact receptor when complexed to DNA …

Background Epidemiological and clinical studies have largely demonstrated major
differences in the prevalence of metabolic disorders in males and females, but the biological …

The ovarian steroid hormone progesterone and its nuclear receptor, the Progesterone
Receptor (PR), play an essential role in the regulation of cell proliferation and differentiation …

Human estrogen receptor alpha (hERα) is a hormone-responsive nuclear receptor (NR)
involved in cell growth and survival that contains both a DNA-binding domain (DBD) and a …

Measurements from small‐angle X‐ray scattering (SAXS) are highly informative to
determine the structures of bimolecular complexes in solution. Here, current and recent …

Identifying drug target genes in gene expression profiles is not straightforward. Because a
drug targets proteins and not mRNAs, the mRNA expression of drug target genes is not …

Structural determination of protein-protein complexes such as multidomain nuclear
receptors has been challenging for high-resolution structural techniques. Here, we present a …

As shown in our previous study, two alternatively spliced androgen receptor (AR) variants,
which are exclusively expressed in the granulosa cells of patients with polycystic ovary …