Glypicans and heparan sulfate in synaptic development, neural plasticity, and neurological disorders

K Kamimura, N Maeda - Frontiers in neural circuits, 2021 - frontiersin.org
Heparan sulfate proteoglycans (HSPGs) are components of the cell surface and
extracellular matrix, which bear long polysaccharides called heparan sulfate (HS) attached …

[HTML][HTML] Understanding autism spectrum disorders with animal models: applications, insights, and perspectives

Z Li, YX Zhu, LJ Gu, Y Cheng - Zoological research, 2021 - ncbi.nlm.nih.gov
Autism spectrum disorder (ASD) is typically characterized by common deficits in social skills
and repetitive/stereotyped behaviors. It is widely accepted that genetic and environmental …

Mutations in trpγ, the homologue of TRPC6 autism candidate gene, causes autism-like behavioral deficits in Drosophila

A Palacios-Muñoz, D de Paula Moreira, V Silva… - Molecular …, 2022 - nature.com
Abstract Autism Spectrum Disorder (ASD) is characterized by impaired social
communication, restricted interests, and repetitive and stereotyped behaviors. The TRPC6 …

Decreased phenol sulfotransferase activities associated with hyperserotonemia in autism spectrum disorders

C Pagan, M Benabou, C Leblond, F Cliquet… - Translational …, 2021 - nature.com
Hyperserotonemia is the most replicated biochemical abnormality associated with autism
spectrum disorders (ASD). However, previous studies of serotonin synthesis, catabolism …

DGRPool, a web tool leveraging harmonized Drosophila Genetic Reference Panel phenotyping data for the study of complex traits

V Gardeux, RPJ Bevers, FPA David, E Rosschaert… - Elife, 2024 - elifesciences.org
Genome-wide association studies have advanced our understanding of complex traits, but
studying how a GWAS variant can affect a specific trait in the human population remains …

Loss of NDST1 N-sulfotransferase activity is associated with autosomal recessive intellectual disability

E Khosrowabadi, C Mignon-Ravix… - Human Molecular …, 2024 - academic.oup.com
Intellectual Disability (ID) is the major cause of handicap, affecting nearly 3% of the general
population, and is highly genetically heterogenous with more than a thousand genes …

Recovery from social isolation requires dopamine in males, but not the autism-related gene nlg3 in either sex

RT Yost, AM Scott, JM Kurbaj… - Royal Society …, 2024 - royalsocietypublishing.org
Social isolation causes profound changes in social behaviour in a variety of species.
However, the genetic and molecular mechanisms modulating behavioural responses to …

The ortholog of human ssDNA-binding protein SSBP3 influences neurodevelopment and autism-like behaviors in Drosophila melanogaster

S Salim, S Hussain, A Banu, SBM Gowda… - PLoS …, 2023 - journals.plos.org
1p32. 3 microdeletion/duplication is implicated in many neurodevelopmental disorders-like
phenotypes such as developmental delay, intellectual disability, autism …

[HTML][HTML] Investigating rare and ultrarare epilepsy syndromes with Drosophila models

P Lasko, K Lüthy - Faculty Reviews, 2021 - ncbi.nlm.nih.gov
One in three epilepsy cases is drug resistant, and seizures often begin in infancy, when they
are life-threatening and when therapeutic options are highly limited. An important tool for …

An unbiased drug screen for seizure suppressors in duplication 15q syndrome reveals 5-HT1A and dopamine pathway activation as potential therapies

B Roy, J Han, KA Hope, TL Peters, G Palmer… - Biological …, 2020 - Elsevier
Abstract Background Duplication 15q (Dup15q) syndrome is a rare neurogenetic disorder
characterized by autism and pharmacoresistant epilepsy. Most individuals with isodicentric …