Over the past year, numerous studies in the peer reviewed and preprint literature have
reported on the virological, epidemiological and clinical characteristics of the coronavirus …

Despite its clinical importance, the SARS-CoV-2 gene set remains unresolved, hindering
dissection of COVID-19 biology. We use comparative genomics to provide a high …

Immunodominance is a complex and highly debated topic of T cell biology. The current
SARS-CoV-2 pandemic has provided the opportunity to profile adaptive immune responses …

The coronavirus disease-2019 (COVID-19) pandemic has caused an enormous loss of lives.
Various clinical trials of vaccines and drugs are being conducted worldwide; nevertheless …

Viruses rely on the host translation machinery to synthesize their own proteins.
Consequently, they have evolved varied mechanisms to co-opt host translation for their …

The pathogenic mechanisms underlying severe SARS-CoV-2 (severe acute respiratory
syndrome coronavirus 2) infection remain largely unelucidated. High-throughput …

HLA molecules are key restrictive elements to present intracellular antigens at the
crossroads of an effective T-cell response against SARS-CoV-2. To determine the impact of …

COVID-19 presents a complex disease that needs to be addressed using systems medicine
approaches that include genome-scale metabolic models (GEMs). Previous studies have …

Immunotherapies have emerged to treat diseases by selectively modulating a patient's
immune response. Although the roles of T and B cells in adaptive immunity have been well …

Modifications in HLA‐I expression are found in many viral diseases. They represent one of
the immune evasion strategies most widely used by viruses to block antigen presentation …