Purpose Emerging evidence suggests a detrimental prognostic association between
radiation-induced lymphopenia (RIL) and pathologic response, progression-free survival …

While proton radiation therapy offers substantially better dose distribution characteristics
than photon radiation therapy in certain clinical applications, data demonstrating a …

Radiotherapy is one of the most effective and frequently used treatments for a wide range of
cancers. In addition to its direct anti-cancer cytotoxic effects, ionising radiation can augment …

Despite significant advances in our knowledge regarding the genetics and molecular
biology of gliomas over the past two decades and hundreds of clinical trials, no effective …

Purpose Immune system modulation, with the use of immune checkpoint inhibitors, has
drastically changed the field of oncology. Strong preclinical data indicate that radiation …

Backgrounds The lymphocyte to C-reactive protein (CRP) ratio (LCR) is an indicator of
systemic inflammation and host–tumor cell interactions. The aim of this study was to …

Glioblastoma is the most common brain malignancy with devastating prognosis. Numerous
clinical trials using various target therapeutic agents have failed and recent clinical trials …

Purpose Addressing lymphopenia in cancer patients has been suggested as a novel
immunotherapeutic strategy. As interleukin‐7 (IL‐7) is necessary for proliferation of …

Glioblastoma, the most prevalent malignant primary brain tumor, presents substantial
treatment challenges because of its inherent aggressiveness and limited therapeutic …

Background Lymphopenia frequently occurs after concomitant chemoradiation (CCRT) in
patients with glioblastoma (GBM) and is associated with worse overall survival (OS). A few …