Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review
P Csermely, T Korcsmáros, HJM Kiss, G London… - Pharmacology & …, 2013 - Elsevier
Despite considerable progress in genome-and proteome-based high-throughput screening
methods and in rational drug design, the increase in approved drugs in the past decade did …
methods and in rational drug design, the increase in approved drugs in the past decade did …
Bioinformatic tools for microRNA dissection
Recently, microRNAs (miRNAs) have emerged as important elements of gene regulatory
networks. MiRNAs are endogenous single-stranded non-coding RNAs (∼ 22-nt long) that …
networks. MiRNAs are endogenous single-stranded non-coding RNAs (∼ 22-nt long) that …
SignaLink 2–a signaling pathway resource with multi-layered regulatory networks
Background Signaling networks in eukaryotes are made up of upstream and downstream
subnetworks. The upstream subnetwork contains the intertwined network of signaling …
subnetworks. The upstream subnetwork contains the intertwined network of signaling …
[HTML][HTML] The NRF2-related interactome and regulome contain multifunctional proteins and fine-tuned autoregulatory loops
NRF2 is a well-known, master transcription factor (TF) of oxidative and xenobiotic stress
responses. Recent studies uncovered an even wider regulatory role of NRF2 influencing …
responses. Recent studies uncovered an even wider regulatory role of NRF2 influencing …
Autophagy Regulatory Network—A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy
Autophagy is a complex cellular process having multiple roles, depending on tissue,
physiological, or pathological conditions. Major post-translational regulators of autophagy …
physiological, or pathological conditions. Major post-translational regulators of autophagy …
An in silicoanalysis of dynamic changes in microRNA expression profiles in stepwise development of nasopharyngeal carcinoma
Z Luo, L Zhang, Z Li, X Li, G Li, H Yu, C Jiang… - BMC medical …, 2012 - Springer
Background MicroRNAs (miRNAs) are small non-coding RNAs that participate in the
spatiotemporal regulation of messenger RNA (mRNA) and protein synthesis. Recent studies …
spatiotemporal regulation of messenger RNA (mRNA) and protein synthesis. Recent studies …
Computational analysis of target hub gene repression regulated by multiple and cooperative miRNAs
MicroRNA (miRNA) target hubs are genes that can be simultaneously targeted by a
comparatively large number of miRNAs, a class of non-coding RNAs that mediate post …
comparatively large number of miRNAs, a class of non-coding RNAs that mediate post …
[HTML][HTML] The synovium attenuates cartilage degeneration in KOA through activation of the Smad2/3-Runx1 cascade and chondrogenesis-related miRNAs
X Zhao, F Meng, S Hu, Z Yang, H Huang… - … Therapy-Nucleic Acids, 2020 - cell.com
Knee osteoarthritis (KOA) is a highly prevalent disabling joint disease in aged people.
Progressive cartilage degradation is the hallmark of KOA, but its deeper mechanism remains …
Progressive cartilage degradation is the hallmark of KOA, but its deeper mechanism remains …
Bioinformatics accelerates the major tetrad: a real boost for the pharmaceutical industry
With advanced technology and its development, bioinformatics is one of the avant-garde
fields that has managed to make amazing progress in the pharmaceutical–medical field by …
fields that has managed to make amazing progress in the pharmaceutical–medical field by …
RNA-KG: An ontology-based knowledge graph for representing interactions involving RNA molecules
The" RNA world" represents a novel frontier for the study of fundamental biological
processes and human diseases and is paving the way for the development of new drugs …
processes and human diseases and is paving the way for the development of new drugs …