The developmental and epileptic encephalopathies encompass a group of rare syndromes
characterised by severe drug-resistant epilepsy with onset in childhood and significant …

Developmental and epileptic encephalopathies, the most severe group of epilepsies, are
characterized by seizures and frequent epileptiform activity associated with developmental …

Epilepsy is a common brain disorder, characterized by spontaneous recurrent seizures, with
associated neuropsychiatric and cognitive comorbidities and increased mortality. Although …

We performed a systematic literature review and narrative synthesis according to a pre‐
registered protocol (Prospero: CRD42022376561) to identify the evidence associated with …

Objective This study was undertaken to assess the safety and efficacy of fenfluramine in the
treatment of convulsive seizures in patients with Dravet syndrome. Methods This multicenter …

Fenfluramine (Fintepla®) is an oral anti-seizure medication (ASM) with a novel mechanism
of action consisting of activity in the serotonergic system coupled with positive allosteric …

Dravet syndrome (DS) is a form of genetic refractory epilepsy. More than 80% of DS patients
carry pathogenic SCN1A mutations, and this percentage is actually higher due to false …

Recent advances in pharmacotherapy for epilepsy : Current Opinion in Neurology Recent
advances in pharmacotherapy for epilepsy : Current Opinion in Neurology Log in or Register …

Epilepsy affects approximately 1% of the world population. Patients have recurrent seizures,
increased physical and psychiatric comorbidities, and higher mortality rate than the general …

Aim To describe the experiences and unmet medical care needs of a group of parents of
children with developmental and epileptic encephalopathies (DEEs) caused by the SCN1A …