Liver fibrosis has evolved in the past 20 years from a pure laboratory discipline to an area of
great bedside relevance to practicing hepatologists. This evolution reflects growing awarenessnotonlyofthemolecularunderpinn …

Hepatic fibrosis is a scarring process that is associated with an increased and altered
deposition of extracellular matrix in liver. At the cellular and molecular level, this progressive …

Background & Aims: The purpose of our study was to prospectively compare the success
rate and diagnostic accuracy of magnetic resonance elastography, ultrasound elastography …

In the liver, the progressive accumulation of connective tissue, a complex and dynamic
process termed fibrosis, represents a very frequent event following a repeated or chronic …

Chronic liver injury and inflammation triggered by metabolic abnormalities initiate the
activation of hepatic stellate cells (HSCs), driving fibrosis and parenchymal dysfunction …

In a search of new bone proteins, the glycoprotein YKL-40 was identified in 1989 to be
secreted in vitro in large amount by the human osteosarcoma cell line MG63. The protein …

Background & Aims Hepatic stellate cells (HSCs) play a key role in liver fibrosis in various
chronic liver disorders including nonalcoholic fatty liver disease (NAFLD). The development …

Background & Aims: Circulating levels of angiotensin II (ANGII), a powerful vasoconstrictor
factor, are frequently increased in chronic liver diseases. In these conditions, hepatic stellate …

Liver fibrosis, a wound‐healing response to a variety of chronic stimuli, is characterized by
excessive deposition of extracellular matrix (ECM) proteins, of which type I collagen …

Background & Aims: The ligand-dependent transcription factor peroxisome proliferator-
activated receptor γ (PPARγ) is expressed in hepatic stellate cells (HSC), and its …