Oxidative stress, mitochondrial dysfunction, and neuroprotection of polyphenols with respect to resveratrol in Parkinson's disease
HC Kung, KJ Lin, CT Kung, TK Lin - Biomedicines, 2021 - mdpi.com
Parkinson's disease (PD) is the second most common neurodegenerative disease and is
characterized by dopaminergic neuronal loss. The exact pathogenesis of PD is complex and …
characterized by dopaminergic neuronal loss. The exact pathogenesis of PD is complex and …
Molecular and supramolecular structure of the mitochondrial oxidative phosphorylation system: implications for pathology
Under aerobic conditions, mitochondrial oxidative phosphorylation (OXPHOS) converts the
energy released by nutrient oxidation into ATP, the currency of living organisms. The whole …
energy released by nutrient oxidation into ATP, the currency of living organisms. The whole …
Structure of a complete ATP synthase dimer reveals the molecular basis of inner mitochondrial membrane morphology
We determined the structure of a complete, dimeric F 1 F o-ATP synthase from yeast
Yarrowia lipolytica mitochondria by a combination of cryo-EM and X-ray crystallography. The …
Yarrowia lipolytica mitochondria by a combination of cryo-EM and X-ray crystallography. The …
High-resolution cryo-EM analysis of the yeast ATP synthase in a lipid membrane
INTRODUCTION The mitochondrial adenosine triphosphate (ATP) synthase is the enzyme
responsible for the synthesis of more than 90% of the ATP produced by mammalian cells …
responsible for the synthesis of more than 90% of the ATP produced by mammalian cells …
Molecular mechanism on forcible ejection of ATPase inhibitory factor 1 from mitochondrial ATP synthase
IF1 is a natural inhibitor protein for mitochondrial FoF1 ATP synthase that blocks catalysis
and rotation of the F1 by deeply inserting its N-terminal helices into F1. A unique feature of …
and rotation of the F1 by deeply inserting its N-terminal helices into F1. A unique feature of …
Structure of ATP synthase from Paracoccus denitrificans determined by X-ray crystallography at 4.0 Å resolution
E Morales-Rios, MG Montgomery… - Proceedings of the …, 2015 - National Acad Sciences
The structure of the intact ATP synthase from the α-proteobacterium Paracoccus
denitrificans, inhibited by its natural regulatory ζ-protein, has been solved by X-ray …
denitrificans, inhibited by its natural regulatory ζ-protein, has been solved by X-ray …
[HTML][HTML] The ATPase Inhibitory Factor 1 (IF1): A master regulator of energy metabolism and of cell survival
J García-Bermúdez, JM Cuezva - Biochimica et Biophysica Acta (BBA) …, 2016 - Elsevier
In this contribution we summarize most of the findings reported for the molecular and cellular
biology of the physiological inhibitor of the mitochondrial H+-ATP synthase, the engine of …
biology of the physiological inhibitor of the mitochondrial H+-ATP synthase, the engine of …
ATP synthase diseases of mitochondrial genetic origin
Devastating human neuromuscular disorders have been associated to defects in the ATP
synthase. This enzyme is found in the inner mitochondrial membrane and catalyzes the last …
synthase. This enzyme is found in the inner mitochondrial membrane and catalyzes the last …
TNK2/ACK1-mediated phosphorylation of ATP5F1A (ATP synthase F1 subunit alpha) selectively augments survival of prostate cancer while engendering …
S Chouhan, M Sawant, C Weimholt, J Luo… - Autophagy, 2023 - Taylor & Francis
The challenge of rapid macromolecular synthesis enforces the energy-hungry cancer cell
mitochondria to switch their metabolic phenotypes, accomplished by activation of oncogenic …
mitochondria to switch their metabolic phenotypes, accomplished by activation of oncogenic …
The ATP synthase deficiency in human diseases
Human diseases range from gene-associated to gene-non-associated disorders, including
age-related diseases, neurodegenerative, neuromuscular, cardiovascular, diabetic …
age-related diseases, neurodegenerative, neuromuscular, cardiovascular, diabetic …