Hyperkateifia and stress-induced alcohol cravings drive relapse in individuals with alcohol
use disorder (AUD). The brain stress signal norepinephrine (also known as noradrenaline) …

Objective The limited understanding of the molecular mechanism for oral submucosal
fibrosis (OSF) poses challenges to the development of effective prevention and treatment …

Corticotropin-releasing factor (CRF, encoded by Crh) signaling is thought to play a critical
role in the development of excessive alcohol drinking and the emotional and physical pain …

Downstream products of alcohol metabolism can impact the level of acetylated alpha-tubulin
through the production of acetyl-CoA and the effects of acetylase alpha-tubulin N …

To date, there are only limited pharmacological treatments to cure AUD and the success rate
is very low. Therefore, new therapeutic routes are warranted. This thesis aims to contribute …