Epigenetic modifications in head and neck cancer

J Gaździcka, K Gołąbek, JK Strzelczyk… - Biochemical …, 2020 - Springer
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common human
malignancy in the world, with high mortality and poor prognosis for patients. Among the risk …

KRAB-ZFP transcriptional regulators acting as oncogenes and tumor suppressors: an overview

J Sobocińska, S Molenda, M Machnik… - International journal of …, 2021 - mdpi.com
Krüppel-associated box zinc finger proteins (KRAB-ZFPs) constitute the largest family of
transcriptional factors exerting co-repressor functions in mammalian cells. In general, KRAB …

LRPPRC: a multifunctional protein involved in energy metabolism and human disease

J Cui, L Wang, X Ren, Y Zhang, H Zhang - Frontiers in physiology, 2019 - frontiersin.org
The pentatricopeptide repeat (PPR) family plays a major role in RNA stability, regulation,
processing, splicing, translation, and editing. Leucine-rich PPR-motif-containing protein …

The enhanced genomic 6 mA metabolism contributes to the proliferation and migration of TSCC cells

L Xi, Y Yang, Y Xu, F Zhang, J Li, X Liu… - International Journal of …, 2022 - nature.com
In contrast to the well-established genomic 5-methylcytosine (5mC), the existence of N6-
methyladenine (6 mA) in eukaryotic genomes was discovered only recently. Initial studies …

lncRNA LIFR-AS1 suppresses invasion and metastasis of non-small cell lung cancer via the miR-942-5p/ZNF471 axis

Q Wang, J Wu, H Huang, Y Jiang, Y Huang… - Cancer cell …, 2020 - Springer
Abstract Background MicroRNA 942-5p (miR-942-5p) has been reported to promote
migration and invasion in non-small cell lung cancer (NSCLC), but the underlying …

The tumor suppressor Zinc finger protein 471 suppresses breast cancer growth and metastasis through inhibiting AKT and Wnt/β-catenin signaling

C Tao, J Luo, J Tang, D Zhou, S Feng, Z Qiu, TC Putti… - Clinical …, 2020 - Springer
Background Zinc-finger protein 471 (ZNF471) is a member of the Krüppel-associated box
domain zinc finger protein (KRAB-ZFP) family. ZNF471 is methylated in squamous cell …

[HTML][HTML] 19q13 KRAB zinc-finger protein ZNF471 activates MAPK10/JNK3 signaling but is frequently silenced by promoter CpG methylation in esophageal cancer

R Sun, T Xiang, J Tang, W Peng, J Luo, L Li, Z Qiu… - Theranostics, 2020 - ncbi.nlm.nih.gov
Zinc-finger proteins (ZFPs) are the largest transcription factor family in mammals, involved in
the regulation of multiple physiologic processes including cell differentiation, proliferation …

Zinc-finger protein 471 suppresses gastric cancer through transcriptionally repressing downstream oncogenic PLS3 and TFAP2A

L Cao, S Wang, Y Zhang, KC Wong, G Nakatsu… - Oncogene, 2018 - nature.com
Abstract Zinc-finger protein 471 (ZNF471) was preferentially methylated in gastric cancer
using promoter methylation array. The role of ZNF471 in human cancer is unclear. Here we …

[HTML][HTML] ZNF471 Interacts with BANP to Reduce Tumour Malignancy by Inactivating PI3K/AKT/mTOR Signalling but is Frequently Silenced by Aberrant Promoter …

X Wang, L Yao, Z Li, J Zhang, M Ruan… - … Journal of Biological …, 2024 - ncbi.nlm.nih.gov
Background: Renal cell carcinoma (RCC) is one of the most common malignant tumours of
the urinary system. However, the aetiology and pathogenesis of RCC remain unclear. The …

ZNF471 modulates EMT and functions as methylation regulated tumor suppressor with diagnostic and prognostic significance in cervical cancer

S Bhat, SP Kabekkodu, D Adiga, R Fernandes… - Cell Biology and …, 2021 - Springer
Cervical cancer (CC) is a leading cause of cancer-related death among women in
developing countries. However, the underlying mechanisms and molecular targets for …