B cells and tertiary lymphoid structures: friends or foes in cancer immunotherapy?
Tumor cells pose a challenge to the adaptive immune system, and its key cell types, T and B
cells, have frequently been associated with an improved prognosis. The success of immune …
cells, have frequently been associated with an improved prognosis. The success of immune …
B cell orchestration of anti-tumor immune responses: a matter of cell localization and communication
The immune system plays a crucial role in cancer development either by fostering tumor
growth or destroying tumor cells, which has open new avenues for cancer immunotherapy. It …
growth or destroying tumor cells, which has open new avenues for cancer immunotherapy. It …
Neoantigen-driven B cell and CD4 T follicular helper cell collaboration promotes anti-tumor CD8 T cell responses
Summary CD4 T follicular helper (TFH) cells support B cells, which are critical for germinal
center (GC) formation, but the importance of TFH-B cell interactions in cancer is unclear. We …
center (GC) formation, but the importance of TFH-B cell interactions in cancer is unclear. We …
Development and validation of a machine learning model for detection and classification of tertiary lymphoid structures in gastrointestinal cancers
Importance Tertiary lymphoid structures (TLSs) are associated with a favorable prognosis
and improved response to cancer immunotherapy. The current approach for evaluation of …
and improved response to cancer immunotherapy. The current approach for evaluation of …
The presence of tertiary lymphoid structures provides new insight into the clinicopathological features and prognosis of patients with breast cancer
B Wang, J Liu, Y Han, Y Deng, J Li, Y Jiang - Frontiers in immunology, 2022 - frontiersin.org
Background Tertiary lymphoid structures (TLSs) have been proven to be predictive
biomarkers of favorable clinical outcomes and response to immunotherapies in several solid …
biomarkers of favorable clinical outcomes and response to immunotherapies in several solid …
[HTML][HTML] Maturation and abundance of tertiary lymphoid structures are associated with the efficacy of neoadjuvant chemoimmunotherapy in resectable non-small cell …
X Sun, W Liu, L Sun, H Mo, Y Feng, X Wu… - … for ImmunoTherapy of …, 2022 - ncbi.nlm.nih.gov
Tertiary lymphoid structures (TLS) existence is correlated with favorable prognosis in many
types of cancer including non-small cell lung cancer (NSCLC). However, TLS formation and …
types of cancer including non-small cell lung cancer (NSCLC). However, TLS formation and …
[HTML][HTML] Characterization of intratumoral tertiary lymphoid structures in pancreatic ductal adenocarcinoma: cellular properties and prognostic significance
X Zou, X Lin, H Cheng, Y Chen, R Wang… - … for ImmunoTherapy of …, 2023 - ncbi.nlm.nih.gov
Background Tumor-associated tertiary lymphoid structures (TLSs) are functional immune-
responsive niches that are not fully understood in pancreatic ductal adenocarcinoma …
responsive niches that are not fully understood in pancreatic ductal adenocarcinoma …
Intratumoral tertiary lymphoid structures promote patient survival and immunotherapy response in head neck squamous cell carcinoma
Z Liu, X Meng, X Tang, W Zou, Y He - Cancer Immunology …, 2023 - Springer
Tertiary lymphoid structures (TLSs) hold the potential role in the prediction of
immunotherapy response in several clinical trials. TLSs in head neck squamous cell …
immunotherapy response in several clinical trials. TLSs in head neck squamous cell …
Spatial positioning of immune hotspots reflects the interplay between B and T cells in lung squamous cell carcinoma
Beyond tertiary lymphoid structures, a significant number of immune-rich areas without
germinal center-like structures are observed in non–small cell lung cancer. Here, we …
germinal center-like structures are observed in non–small cell lung cancer. Here, we …
Tumor battlefield within inflamed, excluded or desert immune phenotypes: the mechanisms and strategies
S Zheng, W Wang, L Shen, Y Yao, W Xia… - … Hematology & Oncology, 2024 - Springer
The tumor microenvironment demonstrates great immunophenotypic heterogeneity, which
has been leveraged in traditional immune-hot/cold tumor categorization based on the …
has been leveraged in traditional immune-hot/cold tumor categorization based on the …