Wnt signaling is a highly conserved pathway crucial for development and homeostasis of
multicellular organisms. Secreted Wnt ligands bind Frizzled receptors to regulate diverse …

Various cellular replacement therapies using in vitro generated cells to replace damaged
tissue have been proposed as strategies to alleviate hearing loss. All such therapies must …

Hearing and balance deficits often affect humans and other mammals permanently, because
their ears stop producing hair cells within a few days after birth. But production occurs …

Purpose Cisplatin is a critical component of first‐line chemotherapy for several cancers, but
causes peripheral sensory neuropathy, hearing loss, and tinnitus. We aimed to identify …

Age-related neurosensory deficit of the inner ear is mostly due to a loss of hair cells (HCs).
Development of stem cell-based therapy requires a better understanding of factors and …

Vertebrate embryogenesis gives rise to all cell types of an organism through the
development of many unique lineages derived from the three primordial germ layers. The …

Background: Vertebrate body axis extension occurs in a head‐to‐tail direction from a caudal
progenitor zone that responds to interacting signals. Wnt/β‐catenin signaling is critical for …

In zebrafish, sensory epithelia and neuroblasts of the inner ear form simultaneously in
abutting medial and lateral domains, respectively, in the floor of the otic vesicle. Previous …

Abstract Small Tail Han Sheep is a highly valued local breed in China because of their
precocity, perennial estrus, and high fecundity. The average annual lambing rate of ewes is …

Background In multiple vertebrate organisms, including chick, Xenopus, and zebrafish,
Fibroblast Growth Factor (FGF) and Wnt signaling cooperate during formation of the otic …