[HTML][HTML] Bilayer forming phospholipids as targets for cancer therapy

C Stoica, AK Ferreira, K Hannan, M Bakovic - International Journal of …, 2022 - mdpi.com
Phospholipids represent a crucial component for the structure of cell membranes.
Phosphatidylcholine and phosphatidylethanolamine are two phospholipids that comprise …

[HTML][HTML] Historical perspective: phosphatidylserine and phosphatidylethanolamine from the 1800s to the present

JE Vance - Journal of lipid research, 2018 - ASBMB
This article provides a historical account of the discovery, chemistry, and biochemistry of two
ubiquitous phosphoglycerolipids, phosphatidylserine (PS) and phosphatidylethanolamine …

Mutations in PCYT2 disrupt etherlipid biosynthesis and cause a complex hereditary spastic paraplegia

FM Vaz, JH McDermott, M Alders, SB Wortmann… - Brain, 2019 - academic.oup.com
Abstract CTP: phosphoethanolamine cytidylyltransferase (ET), encoded by PCYT2, is the
rate-limiting enzyme for phosphatidylethanolamine synthesis via the CDP-ethanolamine …

[HTML][HTML] A homoeostatic switch causing glycerol-3-phosphate and phosphoethanolamine accumulation triggers senescence by rewiring lipid metabolism

K Tighanimine, JA Nabuco Leva Ferreira Freitas… - Nature …, 2024 - nature.com
Cellular senescence affects many physiological and pathological processes and is
characterized by durable cell cycle arrest, an inflammatory secretory phenotype and …

Structural covariance networks in schizophrenia: A systematic review Part I

K Prasad, J Rubin, A Mitra, M Lewis, N Theis… - Schizophrenia …, 2022 - Elsevier
Background Schizophrenia is proposed as a disorder of dysconnectivity. However,
examination of complexities of dysconnectivity has been challenging. Structural covariance …

[HTML][HTML] Choline transporter-like proteins 1 and 2 are newly identified plasma membrane and mitochondrial ethanolamine transporters

A Taylor, S Grapentine, J Ichhpuniani… - Journal of Biological …, 2021 - ASBMB
The membrane phospholipids phosphatidylcholine and phosphatidylethanolamine (PE) are
synthesized de novo by the CDP-choline and CDP-ethanolamine (Kennedy) pathway, in …

Candida tropicalis prompted effectively simultaneous removal of carbon, nitrogen and phosphorus in activated sludge reactor: Microbial community succession and …

Y He, Z Song, X Dong, Q Zheng, X Peng, X Jia - Bioresource Technology, 2022 - Elsevier
A new Candida tropicalis that simultaneously remove nitrogen and phosphorus, and
degrade organic matters was isolated. Three continuous stirred tank reactors inoculated with …

Membrane lipids under norm and pathology

BA Basheer Abdullah Marzoog… - European Journal of …, 2021 - cejsh.icm.edu.pl
Introduction. Lipid is an essential component of the cell and its organelles membrane. The
uniqueness and selectivity of lipids to specific functions and asymmetry of lipid distribution in …

[HTML][HTML] Protein kinase C at the crossroad of mutations, cancer, targeted therapy and immune response

A Aquino, N Bianchi, A Terrazzan, O Franzese - Biology, 2023 - mdpi.com
Simple Summary This review aims to analyze the clinical drawbacks faced by PKC inhibitors
and uncovering aspects that might potentially interfere with the clinical outcome of …

[HTML][HTML] Pcyt2 deficiency causes age-dependant development of nonalcoholic steatohepatitis and insulin resistance that could be attenuated with …

S Grapentine, RK Singh, P Basu, S Sivanesan… - Scientific Reports, 2022 - nature.com
The mechanisms of NASH development in the context of age and genetics are not fully
elucidated. This study investigates the age-dependent liver defects during NASH …