The metabolic face of migraine—from pathophysiology to treatment

EC Gross, M Lisicki, D Fischer, PS Sándor… - Nature Reviews …, 2019 - nature.com
Migraine can be regarded as a conserved, adaptive response that occurs in genetically
predisposed individuals with a mismatch between the brain's energy reserve and workload …

[HTML][HTML] The role of nutrients in the pathogenesis and treatment of migraine headaches

E Nattagh-Eshtivani, MA Sani, M Dahri… - Biomedicine & …, 2018 - Elsevier
Objective Migraine as a disabling neurovascular disease affects 6% of men and 18% of
women worldwide. The deficiency of many nutrients including magnesium, niacin, riboflavin …

Potential protective mechanisms of ketone bodies in migraine prevention

EC Gross, RJ Klement, J Schoenen, DP D'Agostino… - Nutrients, 2019 - mdpi.com
An increasing amount of evidence suggests that migraines are a response to a cerebral
energy deficiency or oxidative stress levels that exceed antioxidant capacity. The ketogenic …

Oxidative stress and DNA damage in patients with migraine

S Geyik, E Altunısık, AM Neyal, S Taysi - The journal of headache and pain, 2016 - Springer
Background Oxidative stress is implicated in the pathogenesis of migraine, but no published
studies have examined both oxidative stress levels and oxidative DNA damage on the same …

An investigation of oxidant/antioxidant balance in patients with migraine: a case-control study

M Togha, S Razeghi Jahromi, Z Ghorbani, A Ghaemi… - BMC neurology, 2019 - Springer
Background In recent years, the role of neuroinflammation and oxidative stress in migraine
pathogenesis has achieved considerable interest; however, to date findings are equivocal …

Unveiling the therapeutic potential of Dl-3-n-butylphthalide in NTG-induced migraine mouse: activating the Nrf2 pathway to alleviate oxidative stress and …

Y Liu, Z Gong, D Zhai, C Yang, G Lu, S Wang… - The Journal of …, 2024 - Springer
Background Migraine stands as a prevalent primary headache disorder, with prior research
highlighting the significant involvement of oxidative stress and inflammatory pathways in its …

The effect of kefir produced from natural kefir grains on the intestinal microbial populations and antioxidant capacities of Balb/c mice

FS Erdogan, S Ozarslan, ZB Guzel-Seydim… - Food Research …, 2019 - Elsevier
Kefir is a probiotic and fermented dairy product authentically produced from kefir grains.
Kefir grain, as a natural starter culture, contains numerous lactic acid bacteria, acetic acid …

Molecular and biochemical evidence on the protective effects of embelin and carnosic acid in isoproterenol-induced acute myocardial injury in rats

C Kocak, FE Kocak, R Akcilar, OO Isiklar, H Kocak… - Life sciences, 2016 - Elsevier
Aims Acute myocardial infarction is a serious acute cardiac disorder and heart disease is still
a major public health problem in adults. We investigated the effects of embelin (EMB) and …

The migraine attack as a homeostatic, neuroprotective response to brain oxidative stress: preliminary evidence for a theory

JM Borkum - Headache: The Journal of Head and Face Pain, 2018 - Wiley Online Library
Background Previous research has suggested that migraineurs show higher levels of
oxidative stress (lipid peroxides) between migraine attacks and that migraine triggers may …

Mitochondrial function and oxidative stress markers in higher-frequency episodic migraine

EC Gross, N Putananickal, AL Orsini, DR Vogt… - Scientific Reports, 2021 - nature.com
Increasing evidence points towards the role of mitochondrial functioning, energy
metabolism, and oxidative stress in migraine. However not all previous research has been …