The Synergistic and Chimeric Mechanism of Bacteriophage Endolysins: Opportunities for Application in Biotherapeutics, Food, and Health Sectors

M Behera, S De, SM Ghorai - Probiotics and Antimicrobial Proteins, 2024 - Springer
A major growing concern in the human and animal health sector is the emergence of
antibiotic-resistant pathogenic bacteria due to the indiscriminate use of antibiotics. The …

Phage-Derived Endolysins Against Resistant Staphylococcus spp.: A Review of Features, Antibacterial Activities, and Recent Applications

M Golban, J Charostad, H Kazemian… - Infectious Diseases and …, 2024 - Springer
Antimicrobial resistance is a significant global public health issue, and the dissemination of
antibiotic resistance in Gram-positive bacterial pathogens has significantly increased …

The food application of a novel Staphylococcus aureus bacteriophage vB_SA_STAP152 and its endolysin LysP152 with high enzymatic activity under cold …

Y Li, J Dai, S Wu, D Rong, J Huang, M Zhao, J Zhang… - Food …, 2025 - Elsevier
Staphylococcus aureus, a foodborne bacterial pathogen, poses a serious challenge due to
antibiotic resistance, highlighting the urgent need for effective and alternative antimicrobial …

Mining and multifaceted applications of phage lysin for combatting Vibrio parahaemolyticus

J Liu, Q Wu, PK Malakar, Y Zhu, Y Zhao… - Food Research …, 2024 - Elsevier
Vibrio parahaemolyticus, a prevalent foodborne pathogen found in both water and seafood,
poses substantial risks to public health. The conventional countermeasure, antibiotics, has …

Expression and characterization of a novel endolysin LysPFX32 as potential biological antimicrobial agent against Pseudomonas fluorescens for pork preservation

P Guan, Z Ming, X Liu, Y Shao, H Pan, Y Ding… - International Journal of …, 2025 - Elsevier
In this study, a novel phage endolysin LysPFX32 was successfully expressed and
characterized to investigate its antibacterial activity against P. fluorescens and its biofilm …

Enzyme-responsive nanoparticles: enhancing the ability of endolysins to eradicate Staphylococcus aureus biofilm

MB Massani, D To, S Meile, M Schmelcher… - Journal of Materials …, 2024 - pubs.rsc.org
Stimuli-responsive nanomaterials show promise in eradicating Staphylococcus aureus
biofilm from implants. Peptidoglycan hydrolases (PGHs) are cationic antimicrobials that can …

Bacterial cellulose with CHAPK-mediated specific antimicrobial activity against Staphylococcus aureus

FG Blanco, C Campano, V Rivero-Buceta… - Cellulose, 2024 - Springer
Wound healing represents a complex biological process often hampered by bacterial
infections, in particular those caused by Staphylococcus aureus, which is already …

Exploring in vitro efficacy of rCHAPk with antibiotic combinations, and promising findings of its therapeutic potential for clinical-originated MRSA wound infection

S Tasdurmazli, I Cinar, M Karamese… - International Journal of …, 2025 - Elsevier
The increasing threat of antimicrobial-resistant bacteria, particularly Staphylococcus aureus,
which rapidly develops multidrug resistance and commonly colonizes wound surfaces …

Characterization and bioinformatic analysis of a new chimeric endolysin against MRSA with great stability

S Momen, N Soleimani, F Azizmohseni, Y Ahmadbeigi… - AMB Express, 2024 - Springer
Antibiotics become less effective in treating infectious diseases as resistance increases. S
taphylococcus aureus is a global problem due to its ability to form biofilms and resistance …

[HTML][HTML] Characterization of Two Novel Endolysins from Bacteriophage PEF1 and Evaluation of Their Combined Effects on the Control of Enterococcus faecalis …

C Wang, J Zhao, Y Lin, SZC Lwin, M El-Telbany… - …, 2024 - pmc.ncbi.nlm.nih.gov
Endolysin, a bacteriophage-derived lytic enzyme, has emerged as a promising alternative
antimicrobial agent against rising multidrug-resistant bacterial infections. Two novel …