Advancement in the development of DNA vaccines against Trypanosoma brucei and future perspective

MT Aleem, F Munir, A Shakoor, F Gao - International …, 2024 - Elsevier
Trypanosomes are the extracellular protozoan parasites that cause human African
trypanosomiasis disease in humans and nagana disease in animals. Tsetse flies act as a …

A Poly(Lactic-co-Glycolic) Acid Nanovaccine Based on Chimeric Peptides from Different Leishmania infantum Proteins Induces Dendritic Cells Maturation and Promotes …

E Athanasiou, M Agallou, S Tastsoglou… - Frontiers in …, 2017 - frontiersin.org
Visceral leishmaniasis, caused by Leishmania (L.) donovani and L. infantum protozoan
parasites, can provoke overwhelming and protracted epidemics, with high case-fatality rates …

Navigating multi-scale cancer systems biology towards model-driven clinical oncology and its applications in personalized therapeutics

MN Gondal, SU Chaudhary - Frontiers in Oncology, 2021 - frontiersin.org
Rapid advancements in high-throughput omics technologies and experimental protocols
have led to the generation of vast amounts of scale-specific biomolecular data on cancer …

Designing of Complex Multi-epitope Peptide Vaccine Based on Omps of Klebsiella pneumoniae: An In Silico Approach

T Farhadi, N Nezafat, Y Ghasemi, Z Karimi… - International Journal of …, 2015 - Springer
Klebsiella pneumoniae is a hospital-acquired pathogen that leads to various infections.
There is a great interest in developing an efficient Klebsiella vaccine and epitope-based …

The utility and limitations of current Web-available algorithms to predict peptides recognized by CD4 T cells in response to pathogen infection

FA Chaves, AH Lee, JL Nayak… - The Journal of …, 2012 - journals.aai.org
The ability to track CD4 T cells elicited in response to pathogen infection or vaccination is
critical because of the role these cells play in protective immunity. Coupled with advances in …

Genome-wide scan for potential CD4+ T-cell vaccine candidates in Candida auris by exploiting reverse vaccinology and evolutionary information

SK Gupta, Ö Osmanoglu, R Minocha, SR Bandi… - Frontiers in …, 2022 - frontiersin.org
Candida auris is a globally emerging fungal pathogen responsible for causing nosocomial
outbreaks in healthcare associated settings. It is known to cause infection in all age groups …

In silico analyses of Wilms׳ tumor protein to designing a novel multi-epitope DNA vaccine against cancer

S Khalili, MR Rahbar, MH Dezfulian… - Journal of theoretical …, 2015 - Elsevier
Predefined and pre-weighted objective criteria and essential role of Wilms׳ tumor wild type
gene (WT1) for maintaining transformed features of cancer cells confirm the high potency of …

Designing and Modeling of Complex DNA Vaccine Based on Tropomyosin Protein of Boophilus Genus Tick

MM Ranjbar, SK Gupta, K Ghorban, S Nabian… - Applied biochemistry …, 2015 - Springer
Boophilus tick is a bloodsucking ectoparasite that transfers some pathogens, reducing
production and thus leading to economical losses in the cattle industry. Tropomyosin (TPM) …

Designing of an epitope-based peptide vaccine against walking pneumonia: an immunoinformatics approach

PA Unni, AMMT Ali, M Rout, A Thabitha, S Vino… - Molecular biology …, 2019 - Springer
Mycoplasma pneumoniae is a substantial respiratory pathogen that develops not only
pneumonia but also other respiratory diseases, which mimic viral respiratory syndromes …

Pan-genomic analysis of the species Salmonella enterica: identification of core essential and putative essential genes

Y Chand, MA Alam, S Singh - Gene Reports, 2020 - Elsevier
Background Essential genes are defined as the minimal gene set required to support
bacterial life. In order to develop new antimicrobials to treat multidrug-resistant pathogens …