The regulation of glycerolipid biosynthesis is critical for homeostasis of cellular lipid stores
and membranes. Here we review the role of lipin phosphatidic acid phosphatase enzymes …

Triacylglycerols (TAG) serve as the predominant form of energy storage in mammalian cells,
and TAG synthesis influences conditions such as obesity, fatty liver, and insulin resistance …

The regulation of cellular lipid storage and membrane lipid composition plays a critical role
in metabolic homeostasis, and dysregulation may contribute to disorders such as obesity …

Phosphatidic acid (PA) is a glycerophospholipid intermediate in the triglyceride synthesis
pathway that has incredibly important structural functions as a component of cell membranes …

Majeed syndrome is a multi-system inflammatory disorder affecting humans that presents
with chronic multifocal osteomyelitis, congenital dyserythropoietic anemia, with or without a …

PURPOSE OF REVIEW This article provides an overview of mitochondrial and metabolic
biology, the genetic mechanisms causing mitochondrial diseases, the clinical features of …

Phospholipid synthesis and fat storage as triglycerides are regulated by lipin phosphatidic
acid phosphatases (PAPs), whose enzymatic PAP function requires association with cellular …

Disorders of lipid metabolism affect several tissues, including skeletal and cardiac muscle
tissues. Lipid myopathies (LM) are rare multi-systemic diseases, which most often are due to …

Background Duchenne muscular dystrophy (DMD) is a progressive and devastating muscle
disease, resulting from the absence of dystrophin. This leads to cell membrane instability …

Lipin 1 regulates glycerolipid homeostasis by acting as a phosphatidic acid
phosphohydrolase (PAP) enzyme in the triglyceride-synthesis pathway and by regulating …