Anti-inflammatory therapeutic mechanisms of natural products: insight from rosemary diterpenes, carnosic acid and carnosol

S Habtemariam - Biomedicines, 2023 - mdpi.com
Carnosic acid (CA) and carnosol (CAR) are two major diterpenes of the rosemary plant
(Rosmarinus officinalis). They possess a phenolic structural moiety and are endowed with …

A cross-talk between sestrins, chronic inflammation and cellular senescence governs the development of age-associated sarcopenia and obesity

G Livshits, A Kalinkovich - Ageing Research Reviews, 2023 - Elsevier
The rapid increase in both the lifespan and proportion of older adults is accompanied by the
unprecedented rise in age-associated chronic diseases, including sarcopenia and obesity …

Targeted therapies of inflammatory diseases with intracellularly gelated macrophages in mice and rats

C Gao, Q Wang, Y Ding, CHT Kwong, J Liu… - Nature …, 2024 - nature.com
Membrane-camouflaged nanomedicines often suffer from reduced efficacy caused by
membrane protein disintegration and spatial disorder caused by separation and reassembly …

[HTML][HTML] S-allylmercapto-N-acetylcysteine ameliorates pulmonary fibrosis in mice via Nrf2 pathway activation and NF-κB, TGF-β1/Smad2/3 pathway suppression

Q Zhang, W Ye, Y Liu, D Niu, X Zhao, G Li, Y Qu… - Biomedicine & …, 2023 - Elsevier
Pulmonary fibrosis (PF) is a chronic lung disease characterised by alveolar inflammatory
injury, alveolar septal thickening, and eventually fibrosis. Patients with severe Coronavirus …

Quercetin influences intestinal dysbacteriosis and delays alveolar epithelial cell senescence by regulating PTEN/PI3K/AKT signaling in pulmonary fibrosis

W Wu, X Wu, L Qiu, R Wan, X Zhu, S Chen… - Naunyn-Schmiedeberg's …, 2024 - Springer
Pulmonary fibrosis is a chronic and progressive lung disease with high mortality. This study
aims to explore the protective mechanism of quercetin against pulmonary fibrosis regarding …

Protective effects of carnosol on renal interstitial fibrosis in a murine model of unilateral ureteral obstruction

JH Park, J Leem, SJ Lee - Antioxidants, 2022 - mdpi.com
Renal fibrosis is a common feature of chronic kidney disease and is a promising therapeutic
target. However, there is still limited treatment for renal fibrosis, so the development of new …

Insights on the mechanism of bleomycin to induce lung injury and associated in vivo models: a review

BL Ayilya, A Balde, M Ramya, S Benjakul… - International …, 2023 - Elsevier
Acute lung injury leads to the development of chronic conditions such as idiopathic
pulmonary fibrosis (IPF), chronic obstructive pulmonary disease (COPD), asthma as well as …

A systematic review of the research progress of traditional Chinese medicine against pulmonary fibrosis: from a pharmacological perspective

S Qin, P Tan, J Xie, Y Zhou, J Zhao - Chinese Medicine, 2023 - Springer
Pulmonary fibrosis is a chronic progressive interstitial lung disease caused by a variety of
etiologies. The disease can eventually lead to irreversible damage to the lung tissue …

Aprepitant exerts anti-fibrotic effect via inhibition of TGF-β/Smad3 pathway in bleomycin-induced pulmonary fibrosis in rats

MZ Mohamed, MFA El Baky, ME Ali… - Environmental Toxicology …, 2022 - Elsevier
Bleomycin is a well-recognized antineoplastic drug. However, pulmonary fibrosis (PF) is
considered to be the principal drawback that greatly limits its use. Here, we sought to …

Carnosol Alleviates Collagen‐Induced Arthritis by Inhibiting Th17‐Mediated Immunity and Favoring Suppressive Activity of Regulatory T Cells

J Chen, N Sun, F Li, H Li, J Tian… - BioMed Research …, 2023 - Wiley Online Library
Current approaches are incurable for rheumatoid arthritis (RA). Regulatory T (Treg) cells
and T helper cells (Th1 and Th17) are crucial in controlling the process of RA, which is …