Sex differences are reported in hippocampal plasticity, cognition, and in a number of
disorders that target the integrity of the hippocampus. For example, meta-analyses reveal …

Recent research suggests that epigenetics, especially DNA methylation, plays a mechanistic
role in aging. Epigenetic clocks, which measure changes in a few hundred specific CpG …

Background Traumatic brain injury (TBI) is a leading cause of death and disability
worldwide. Microglial/macrophage activation and neuroinflammation are key cellular events …

Aging is an inevitable biological process characterized by a progressive decline in
physiological function and increased susceptibility to disease. The detrimental effects of …

Microglia are the tissue-resident macrophage population of the brain, specialized in
supporting the CNS environment and protecting it from endogenous and exogenous insults …

Neurodegenerative diseases (NDs) are a wide class of disorders of the central nervous
system (CNS) with unknown etiology. Several factors were hypothesized to be involved in …

Alzheimer's disease (AD) is an age-associated neurodegenerative disease characterized by
amyloidosis, tauopathy, and activation of microglia, the brain resident innate immune cells …

We aimed to identify diagnosis-specific/transdiagnostic/transoutcome multivariable
candidate predictors (MCPs) of key outcomes in mental disorders. We conducted an …

Age and sex are major risk factors in Alzheimer's disease (AD) with a higher incidence of the
disease in females. Neuroinflammation, which is a hallmark of AD, contributes to disease …

Microglial cells are the scions of foetal macrophages which invade the neural tube early
during embryogenesis. The nervous tissue environment instigates the phenotypic …