Similar to its eukaryotic counterpart, the prokaryotic cytoskeleton is essential for the
structural and mechanical properties of bacterial cells. The essential protein FtsZ is a central …

Antimicrobial resistance to virtually all clinically applied antibiotic classes severely limits the
available options to treat bacterial infections. Hence, there is an urgent need to develop and …

With the emergence of multidrug-resistant bacterial strains, there is a dire need for new drug
targets for antibacterial drug discovery and development. Filamentous temperature sensitive …

In recent years, the rise of antibiotic resistance has become a primary health problem. With
the emergence of bacterial resistance, the need to explore and develop novel antibacterial …

Abstract The Pathogen Box is a 400‐strong collection of drug‐like compounds, selected for
their potential against several of the world's most important neglected tropical diseases …

In search for new molecular entities as anti-TB agents, the benzimidazoquinazoline
polyheterocyclic scaffold has been designed adopting the scaffold hopping strategy. Thirty …

2-Alkyl-1, 2-benzisoselenazol-3 (2 H)-ones, represented by ebselen (1a), are being studied
intensively for a range of medicinal applications. We describe both a new thermal and …

Currently, wide-spread antimicrobials resistance among bacterial pathogens continues
being a dramatically increasing and serious threat to public health, and thus there is a …

Tuberculosis (TB) has become one of the most significant public health problems in recent
years. Antibiotic therapy remains the mainstay of TB control strategies, but the increasing …

Tuberculosis (TB) and its drug resistant forms kills more people than any other infectious
disease. This fact emphasizes the need to identify new drugs to treat TB. 2-Aminothiophenes …