Chemical compounds derived from plants have been used since the origin of human beings
to counteract a number of diseases. Among them, the natural isoquinoline alkaloid …

Isoquinoline alkaloids-enriched herbal plants have been used as traditional folk medicine
for their anti-inflammatory, antimicrobial, and analgesic effects. They induce cell cycle arrest …

Repeated guanine tracts in human and other genomes can form higher-order four stranded
structures, termed quadruplexes. In the human genome they have particular prevalence in …

Telomeres and telomerase are nowadays exploring traits on targets for anticancer therapy.
Telomerase is a unique reverse transcriptase enzyme, considered as a primary factor in …

G-quadruplexes (G4s) are higher-order DNA structures typically present at promoter regions
of genes and telomeres. Here, the G4 formation decreases the replicative DNA at each cell …

The present paper reviews the recent advances in and applications of experimental
techniques used to study interactions between G-quadruplex structures and ligands that are …

The first crystal structure of human telomeric DNA in complex with the natural alkaloid
berberine, produced by different plant families and used in folk medicine for millennia, was …

Cancer has always been a dreadful disease and continues to attract extensive research
investigations. Various targets have been identified to restrain cancer. Among these DNA …

Telomerases are an attractive drug target to develop new generation drugs against cancer.
A telomere appears from the chromosomal termini and protects it from double-stranded DNA …

Berberine is a traditional medicine that has multiple medicinal and agricultural applications.
However, little is known about whether berberine can be a bioactive molecule toward …