Medicinal plants in Brazil: Pharmacological studies, drug discovery, challenges and perspectives

RC Dutra, MM Campos, ARS Santos… - Pharmacological research, 2016 - Elsevier
This review article focuses on pre-clinical and clinical studies with some selected Brazilian
medicinal plants in different areas of interest, conducted by research groups in Brazil and …

[HTML][HTML] Phytochemistry and pharmacology of anti-depressant medicinal plants: A review

J Martins, S Brijesh - Biomedicine & Pharmacotherapy, 2018 - Elsevier
Stress renders an individual to experience mental pressure and exhaustion which brings
about feelings of anxiety, depression, anger and/or other negative emotions. Depression …

Medicinal plants in the treatment of depression: Evidence from preclinical studies

I Moragrega, JL Ríos - Planta medica, 2021 - thieme-connect.com
Medicinal plants and their extracts are natural remedies with enormous potential for treating
various diseases, including depression and anxiety. In the case of depression, hundreds of …

Do other Hypericum species have medical potential as St. John's wort (Hypericum perforatum)?

G Stojanovic, A Dordevic… - Current medicinal …, 2013 - ingentaconnect.com
Among 484 Hypericum L.(Guttiferae/Hypericaceae) species, widespread in warm temperate
areas throughout the world, only H. perforatum is widely used in official medicine …

Uliginosin B, a phloroglucinol derivative from Hypericum polyanthemum: a promising new molecular pattern for the development of antidepressant drugs

AC Stein, AF Viana, LG Müller, JM Nunes… - Behavioural Brain …, 2012 - Elsevier
In this study we have demonstrated that cyclohexane extract of Hypericum polyanthemum
(POL) and its main phloroglucinol derivative uliginosin B (ULI) present antidepressant-like …

Supercritical extraction of Hypericum caprifoliatum using carbon dioxide and ethanol+ water as co-solvent

RN Almeida, RG Neto, FMC Barros, E Cassel… - … and Processing: Process …, 2013 - Elsevier
Hypericum caprifoliatum is a natural source of phloroglucinol derivatives such as
hyperbrasilol B, uliginosin B and japonicin A, compounds with pharmaceutical interest due …

Antinociceptive Activity of Trichilia catigua Hydroalcoholic Extract: New Evidence on Its Dopaminergic Effects

AF Viana, IS Maciel, EM Motta, PC Leal… - Evidence‐Based …, 2011 - Wiley Online Library
Trichilia catigua is a native plant of Brazil; its barks are used by some local pharmaceutical
companies to prepare tonic drinks, such as Catuama. The present study was addressed to …

Dimeric acylphloroglucinols in Hypericum species from sections Brathys and Trigynobrathys

GV Ccana-Ccapatinta, FMC de Barros, H Bridi… - Phytochemistry …, 2015 - Springer
Hypericum is a prolific source of acylphloroglucinol derivatives. Unlike the monomeric
polyisoprenylated acylphloroglucinols hyperforin and adhyperforin, which are the main …

Acute and repeated-doses (28 days) toxicity study of Hypericum polyanthemum Klotzsch ex Reichardt (Guttiferare) in mice

AH Betti, AC Stein, E Dallegrave, ATB Wouters… - Food and Chemical …, 2012 - Elsevier
Hypericum polyanthemum, a South Brazilian species showed antidepressant-like and
antinociceptive effects in rodents. Since limited information is available on the toxicity and …

In silico Prediction of ADMET/Drug-likeness Properties of Bioactive Phloroglucinols from Hypericum Genus

CPM da Silva, GM das Neves, GL Poser… - Medicinal …, 2023 - ingentaconnect.com
Background: Dimeric acylphloroglucinols occurring in species from sections Brathys and
Trigynobrathys of the genus Hypericum exhibit acylfilicinic acid and acylphloroglucinol …