Acute myeloid leukaemia
E Estey, H Döhner - The Lancet, 2006 - thelancet.com
Acute myeloid leukaemia (AML) is a heterogeneous clonal disorder of haemopoietic
progenitor cells and the most common malignant myeloid disorder in adults. The median …
progenitor cells and the most common malignant myeloid disorder in adults. The median …
The European LeukemiaNet AML Working Party consensus statement on allogeneic HSCT for patients with AML in remission: an integrated-risk adapted approach
JJ Cornelissen, A Gratwohl, RF Schlenk… - Nature reviews Clinical …, 2012 - nature.com
Allogeneic haematopoietic stem-cell transplantation (HSCT) is frequently applied as part of
the treatment in patients with acute myeloid leukaemia (AML) in their first or subsequent …
the treatment in patients with acute myeloid leukaemia (AML) in their first or subsequent …
Midostaurin after allogeneic stem cell transplant in patients with FLT3-internal tandem duplication-positive acute myeloid leukemia
RT Maziarz, M Levis, MM Patnaik, BL Scott… - Bone marrow …, 2021 - nature.com
We evaluated standard-of-care (SOC) treatment with or without midostaurin to prevent
relapse following allogeneic hematopoietic stem cell transplant (alloHSCT) in patients with …
relapse following allogeneic hematopoietic stem cell transplant (alloHSCT) in patients with …
Differential impact of allelic ratio and insertion site in FLT3-ITD–positive AML with respect to allogeneic transplantation
RF Schlenk, S Kayser, L Bullinger… - Blood, The Journal …, 2014 - ashpublications.org
The objective was to evaluate the prognostic and predictive impact of allelic ratio and
insertion site (IS) of internal tandem duplications (ITDs), as well as concurrent gene …
insertion site (IS) of internal tandem duplications (ITDs), as well as concurrent gene …
Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia
RF Schlenk, K Döhner, J Krauter… - … England Journal of …, 2008 - Mass Medical Soc
Background Mutations occur in several genes in cytogenetically normal acute myeloid
leukemia (AML) cells: the nucleophosmin gene (NPM1), the fms-related tyrosine kinase 3 …
leukemia (AML) cells: the nucleophosmin gene (NPM1), the fms-related tyrosine kinase 3 …
The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute …
An internal tandem duplication in the fms-like tyrosine kinase 3 gene (FLT3/ITD) is
associated with poor prognosis in acute myeloid leukemia (AML), but the impact of mutant …
associated with poor prognosis in acute myeloid leukemia (AML), but the impact of mutant …
Measurable residual disease at induction redefines partial response in acute myeloid leukemia and stratifies outcomes in patients at standard risk without NPM1 …
Purpose We investigated the effect on outcome of measurable or minimal residual disease
(MRD) status after each induction course to evaluate the extent of its predictive value for …
(MRD) status after each induction course to evaluate the extent of its predictive value for …
[HTML][HTML] Clinical practice recommendation on hematopoietic stem cell transplantation for acute myeloid leukemia patients with FLT3-internal tandem duplication: a …
The FMS-like tyrosine kinase 3 (FLT3) gene is mutated in 25-30% of patients with acute
myeloid leukemia (AML). Because of the poor prognosis associated with FLT3-internal …
myeloid leukemia (AML). Because of the poor prognosis associated with FLT3-internal …
FLT3 mutations in acute myeloid leukemia: what is the best approach in 2013?
M Levis - Hematology 2013, the American Society of …, 2013 - ashpublications.org
Patients with acute myeloid leukemia who harbor an FMS-like tyrosine kinase 3 (FLT3)
mutation present several dilemmas for the clinician. The results of an FLT3 mutation test …
mutation present several dilemmas for the clinician. The results of an FLT3 mutation test …
FLT3 as a therapeutic target in AML: still challenging after all these years
Mutations within the FMS-like tyrosine kinase 3 (FLT3) gene on chromosome 13q12 have
been detected in up to 35% of acute myeloid leukemia (AML) patients and represent one of …
been detected in up to 35% of acute myeloid leukemia (AML) patients and represent one of …