MYC protein interactors in gene transcription and cancer
The transcription factor and oncoprotein MYC is a potent driver of many human cancers and
can regulate numerous biological activities that contribute to tumorigenesis. How a single …
can regulate numerous biological activities that contribute to tumorigenesis. How a single …
KMT2C/D COMPASS complex-associated diseases [KCDCOM-ADs]: an emerging class of congenital regulopathies
WJ Lavery, A Barski, S Wiley, EK Schorry… - Clinical …, 2020 - Springer
The type 2 lysine methyltransferases KMT2C and KMT2D are large, enzymatically active
scaffold proteins that form the core of nuclear regulatory structures known as KMT2C/D …
scaffold proteins that form the core of nuclear regulatory structures known as KMT2C/D …
A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models
Interactions between WD40 repeat domain protein 5 (WDR5) and its various partners such
as mixed lineage leukemia (MLL) and c-MYC are essential for sustaining oncogenesis in …
as mixed lineage leukemia (MLL) and c-MYC are essential for sustaining oncogenesis in …
LncRNA SATB2-AS1 inhibits tumor metastasis and affects the tumor immune cell microenvironment in colorectal cancer by regulating SATB2
M Xu, X Xu, B Pan, X Chen, K Lin, K Zeng, X Liu, T Xu… - Molecular cancer, 2019 - Springer
Background Emerging studies suggest that long non-coding RNAs (lncRNAs) play crucial
roles in colorectal cancer (CRC). Here, we report a lncRNA, SATB2-AS1, which is …
roles in colorectal cancer (CRC). Here, we report a lncRNA, SATB2-AS1, which is …
Tracking the PROTAC degradation pathway in living cells highlights the importance of ternary complex measurement for PROTAC optimization
The multi-step degradation process of PROteolysis TArgeting Chimeras (PROTACs) poses a
challenge for their rational development, as the rate-limiting steps that determine PROTACs …
challenge for their rational development, as the rate-limiting steps that determine PROTACs …
Functional landscape of PCGF proteins reveals both RING1A/B-dependent-and RING1A/B-independent-specific activities
Polycomb repressive complexes 1 and 2 (PRC1 and PRC2) control cell identity by
establishing facultative heterochromatin repressive domains at common sets of target …
establishing facultative heterochromatin repressive domains at common sets of target …
Investigating crosstalk between H3K27 acetylation and H3K4 trimethylation in CRISPR/dCas-based epigenome editing and gene activation
W Zhao, Y Xu, Y Wang, D Gao, J King, Y Xu… - Scientific reports, 2021 - nature.com
Epigenome editing methods enable the precise manipulation of epigenetic modifications,
such as histone posttranscriptional modifications (PTMs), for uncovering their biological …
such as histone posttranscriptional modifications (PTMs), for uncovering their biological …
Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic
Abstract WD repeat domain 5 (WDR5), an integral component of the MLL/KMT2A lysine
methyltransferase complex, is critically involved in oncogenesis and represents an attractive …
methyltransferase complex, is critically involved in oncogenesis and represents an attractive …
Orphan quality control shapes network dynamics and gene expression
All eukaryotes require intricate protein networks to translate developmental signals into
accurate cell fate decisions. Mutations that disturb interactions between network …
accurate cell fate decisions. Mutations that disturb interactions between network …
LncRNA ANRIL acts as a modular scaffold of WDR5 and HDAC3 complexes and promotes alteration of the vascular smooth muscle cell phenotype
C Zhang, S Ge, W Gong, J Xu, Z Guo, Z Liu, X Gao… - Cell death & …, 2020 - nature.com
Many studies have shown that long-noncoding RNA (lncRNA) is associated with
cardiovascular disease, but its molecular mechanism is still unclear. In this study, we …
cardiovascular disease, but its molecular mechanism is still unclear. In this study, we …