Handshakes and fights: the regulatory interplay of RNA-binding proteins

E Dassi - Frontiers in molecular biosciences, 2017 - frontiersin.org
What drives the flow of signals controlling the outcome of post-transcriptional regulation of
gene expression? This regulatory layer, presiding to processes ranging from splicing to …

Post-transcriptional regulation of anti-apoptotic BCL2 family members

J Cui, WJ Placzek - International journal of molecular sciences, 2018 - mdpi.com
Anti-apoptotic B cell lymphoma 2 (BCL2) family members (BCL2, MCL1, BCLxL, BCLW, and
BFL1) are key players in the regulation of intrinsic apoptosis. Dysregulation of these proteins …

Nuclear m6A reader YTHDC1 regulates mRNA splicing

W Xiao, S Adhikari, U Dahal, YS Chen, YJ Hao, BF Sun… - Molecular cell, 2016 - cell.com
The regulatory role of N 6-methyladenosine (m 6 A) and its nuclear binding protein YTHDC1
in pre-mRNA splicing remains an enigma. Here we show that YTHDC1 promotes exon …

SR proteins are NXF1 adaptors that link alternative RNA processing to mRNA export

M Müller-McNicoll, V Botti… - Genes & …, 2016 - genesdev.cshlp.org
Nuclear export factor 1 (NXF1) exports mRNA to the cytoplasm after recruitment to mRNA by
specific adaptor proteins. How and why cells use numerous different export adaptors is …

Differential functions of splicing factors in mammary transformation and breast cancer metastasis

SH Park, M Brugiolo, M Akerman, S Das, L Urbanski… - Cell reports, 2019 - cell.com
Misregulation of alternative splicing is a hallmark of human tumors, yet to what extent and
how it contributes to malignancy are only beginning to be unraveled. Here, we define which …

Structure, activity, and function of PRMT1

C Thiebaut, L Eve, C Poulard, M Le Romancer - Life, 2021 - mdpi.com
PRMT1, the major protein arginine methyltransferase in mammals, catalyzes
monomethylation and asymmetric dimethylation of arginine side chains in proteins. Initially …

Uncovering the impacts of alternative splicing on the proteome with current omics techniques

M Reixachs‐Solé, E Eyras - Wiley Interdisciplinary Reviews …, 2022 - Wiley Online Library
The high‐throughput sequencing of cellular RNAs has underscored a broad effect of isoform
diversification through alternative splicing on the transcriptome. Moreover, the differential …

Alternative polyadenylation: methods, findings, and impacts

W Chen, Q Jia, Y Song, H Fu, G Wei… - Genomics, Proteomics …, 2017 - academic.oup.com
Alternative polyadenylation (APA), a phenomenon that RNA molecules with different 3′
ends originate from distinct polyadenylation sites of a single gene, is emerging as a …

Implementation of CsLIS/NES in linalool biosynthesis involves transcript splicing regulation in Camellia sinensis

GF Liu, JJ Liu, ZR He, FM Wang, H Yang… - Plant, cell & …, 2018 - Wiley Online Library
Volatile terpenoids produced in tea plants (Camellia sinensis) are airborne signals
interacting against other ecosystem members, but also pleasant odorants of tea products …

Structure, activity and function of the PRMT2 protein arginine methyltransferase

V Cura, J Cavarelli - Life, 2021 - mdpi.com
PRMT2 belongs to the protein arginine methyltransferase (PRMT) family, which catalyzes
the arginine methylation of target proteins. As a type I enzyme, PRMT2 produces asymmetric …