Abstract Purpose of Review Our goal is to examine the processes—both central and
peripheral—that underlie the development of peripherally-induced neuropathic pain (pNP) …

Interleukin-6 is an inflammatory cytokine with wide-ranging biological effects. It has been
widely demonstrated that neuroinflammation plays a critical role in the development of …

Effective repair and functional recovery of large peripheral nerve deficits are urgent clinical
needs. A biofunctional electroactive scaffold typically acts as a “bridge” for the repair of large …

Tissue damage, inflammation or injury of the nervous system may result in chronic
neuropathic pain characterised by increased sensitivity to painful stimuli (hyperalgesia), the …

Lysophosphatidic acid (LPA) is a bioactive lipid with activity in the nervous system mediated
by G-protein-coupled receptors. Here, we examined the role of LPA signaling in the …

Lumb & Jones' is the definitive reference in veterinary anesthesia and analgesia, covering
all large and small animal species and a full array of clinical conditions and diseases. This …

Pain has often been regarded merely as a symptom that serves as a passive warning signal
of an underlying disease process. Using this model, the goal of treatment has been to …

Background Postherpetic neuralgia (PHN) is a complication of acute herpes zoster, which is
emerging as a preferred clinical trial model for chronic neuropathic pain. Although there are …

The objective of the present study was to examine the relative contributions of different
dimensions of catastrophic thinking (ie rumination, magnification, helplessness) to the pain …

In the central nervous system (CNS), adenosine is an important neuromodulator and
regulates neuronal and non-neuronal cellular function (eg microglia) by actions on …