When mycophenolic acid (MPA) was originally marketed for immunosuppressive therapy,
fixed doses were recommended by the manufacturer. Awareness of the potential for a more …

The optimal level of immunosuppression in solid organ transplantation, in particular for the
liver, is a delicate balance between the benefit of preventing rejection and the adverse side …

Graves' orbitopathy (GO) is the main extrathyroidal manifestation of Graves' disease (GD).
Choice of treatment should be based on the assessment of clinical activity and severity of …

Background 12 months of oral cyclophosphamide has been shown to alter the progression
of scleroderma-related interstitial lung disease when compared with placebo. However …

Virus-infected cells and cancers share metabolic commonalities that stem from their
insatiable need to replicate while evading the host immune system. These similarities …

Inosine monophosphate dehydrogenase (IMPDH) of human is an attractive target for
immunosuppressive agents. Currently, small-molecule inhibitors do not show good …

Mycophenolate mofetil (MMF) is commonly prescribed and has proven advantages over
other immunosuppressive drugs. However, frequent gastrointestinal side effects through an …

The body's immune system is essential for protecting it from various pathogens and other
external insults. The immune system is tightly regulated and maintained through the …

Liver transplantation (LT) is the standard of care for end-stage liver failure and
hepatocellular carcinoma. Over the years, immunosuppression regimens have improved …

The immunosuppressive agent mycophenolate is used extensively in kidney transplantation,
yet dosing strategy applied varies markedly from fixed dosing (“one-dose-fits-all”), to …