Placental dysfunction underlies increased risk of fetal growth restriction and stillbirth in advanced maternal age women

SC Lean, AEP Heazell, MR Dilworth, TA Mills… - Scientific reports, 2017 - nature.com
Pregnancies in women of advanced maternal age (AMA) are susceptible to fetal growth
restriction (FGR) and stillbirth. We hypothesised that maternal ageing is associated with …

Blood flow and transport in the human placenta

OE Jensen, IL Chernyavsky - Annual review of fluid mechanics, 2019 - annualreviews.org
The placenta is a multifunctional organ that exchanges blood gases and nutrients between a
mother and her developing fetus. In humans, fetal blood flows through intricate networks of …

Computational modeling of the interactions between the maternal and fetal circulations in human pregnancy

AR Clark, TC Lee, JL James - WIREs Mechanisms of Disease, 2021 - Wiley Online Library
In pregnancy, fetal growth is supported by its placenta. In turn, the placenta is nourished by
maternal blood, delivered from the uterus, in which the vasculature is dramatically …

Multiscale modelling of the feto–placental vasculature

AR Clark, M Lin, M Tawhai, R Saghian… - Interface …, 2015 - royalsocietypublishing.org
The placenta provides all the nutrients required for the fetus through pregnancy. It develops
dynamically, and, to avoid rejection of the fetus, there is no mixing of fetal and maternal …

Agent-based model of angiogenesis simulates capillary sprout initiation in multicellular networks

J Walpole, JC Chappell, JG Cluceru… - Integrative …, 2015 - academic.oup.com
Many biological processes are controlled by both deterministic and stochastic influences.
However, efforts to model these systems often rely on either purely stochastic or purely rule …

Associations between the features of gross placental morphology and birthweight

AA Freedman, CJ Hogue, CJ Marsit… - Pediatric and …, 2019 - journals.sagepub.com
The placenta plays a critical role in regulating fetal growth. Recent studies suggest that there
may be sex-specific differences in placental development. The purpose of our study was to …

The role of the 3rs for understanding and modeling the human placenta

J Costa, R Mackay, SC de Aguiar Greca… - Journal of Clinical …, 2021 - mdpi.com
Modeling the physiology of the human placenta is still a challenge, despite the great number
of scientific advancements made in the field. Animal models cannot fully replicate the …

[HTML][HTML] Computational modelling of placental amino acid transfer as an integrated system

N Panitchob, KL Widdows, IP Crocker… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Placental amino acid transfer is essential for fetal development and its impairment is
associated with poor fetal growth. Amino acid transfer is mediated by a broad array of …

Hybrid modeling of tumor-induced angiogenesis

LL Bonilla, V Capasso, M Alvaro, M Carretero - Physical Review E, 2014 - APS
When modeling of tumor-driven angiogenesis, a major source of analytical and
computational complexity is the strong coupling between the kinetic parameters of the …

Maternal affective symptoms and sleep quality have sex-specific associations with placental topography

RG Shah, CM Salafia, T Girardi, C Rukat… - Journal of Affective …, 2024 - Elsevier
Background The impacts of prenatal maternal affective symptoms on the placental structure
are not well-established. Employing Geographic Information System (GIS) spatial …