Tumorigenesis is a complex and dynamic process, consisting of three stages: initiation,
progression, and metastasis. Tumors are encircled by extracellular matrix (ECM) and …

A significant fraction of the total immune cells in the body are located in several hundred
lymph nodes, in which lymphocyte accumulation, activation and proliferation are organized …

Advances in our understanding of the structure and function of the lymphatic system have
made it possible to identify its role in a variety of disease processes. Because it is involved …

Lymph nodes are initial sites for cancer metastasis in many solid tumors. However, their role
in cancer progression is still not completely understood. Emerging evidence suggests that …

Adaptive immune response consists of many highly regulated, multistep cascades that
protect against infection while preserving the health of autologous tissue. The proper …

Malignant tumors of ectodermal or endodermal origin may metastasize to the sentinel lymph
node, the first lymph node encountered by tumor cells that enter lymphatics in the organ of …

Tissue remodeling is a characteristic of many solid tumor malignancies including melanoma.
By virtue of tumor lymphatic transport, remodeling pathways active within the local tumor …

Regional lymph node status is an important prognostic indicator of tumor aggressiveness.
However, early diagnosis of metastasis using intranodal pressure, at a stage when lymph …

Aim: This meta-analysis aims to determine the accuracy of contrast-enhanced
ultrasonography (CEUS) in the qualitative diagnosis of metastatic sentinel lymph node …

Breast cancer treatment has a long, fascinating history. Multimodality therapy utilizes
surgery, systemic therapy and radiation. The role of surgical axillary staging in breast cancer …