Best practices in preclinical algesiometry (pain behaviour testing) have shifted over the past
decade as a result of technological advancements, the continued dearth of translational …

Acute pain signaling has a key protective role and is highly evolutionarily conserved.
Chronic pain, however, is maladaptive, occurring as a consequence of injury and disease …

Distinct types of dorsal root ganglion sensory neurons may have unique contributions to
chronic pain. Identification of primate sensory neuron types is critical for understanding the …

Chronic pain affects one in five of the general population and is the third most important
cause of disability-adjusted life-years globally. Unfortunately, treatment remains inadequate …

Sensory neurons with cell bodies situated in dorsal root ganglia convey information from
external or internal sites of the body such as actual or potential harm, temperature or muscle …

The somatosensory system allows us to detect a diverse range of physical and chemical
stimuli including noxious ones, which can initiate protective reflexes to prevent tissue …

Acute pain is adaptive, but chronic pain is a global challenge. Many chronic pain syndromes
are peripheral in origin and reflect hyperactivity of peripheral pain-signaling neurons …

Voltage-gated sodium channels (Navs) play an important role in human pain sensation.
However, the expression and role of Nav subtypes in native human sensory neurons are …

Vitamin B-6 in the form of pyridoxine (PN) is commonly used by the general population. The
use of PN-containing supplements has gained lots of attention over the past years as they …

The chronic pain syndrome inherited erythromelalgia (IEM) is attributed to mutations in the
voltage-gated sodium channel (NaV) 1.7. Still, recent studies targeting NaV1. 7 in clinical …