The dogma that the genesis of new cells is a negligible event in the adult mammalian brain
has long influenced our perception and understanding of the origin and development of …

The invasion of neoplastic cells into healthy brain tissue is a pathologic hallmark of gliomas
and contributes to the failure of current therapeutic modalities (surgery, radiation and …

Transformed stem cells have been isolated from some human cancers. We report that,
unlike other brain cancers, the lethal glioblastoma multiforme contains neural precursors …

The poor survival of patients with human malignant gliomas relates partly to the inability to
deliver therapeutic agents to the tumor. Because it has been suggested that circulating bone …

The prognosis of patients with malignant glioma is extremely poor, despite the extensive
surgical treatment that they receive and recent improvements in adjuvant radio-and …

Recent pre-clinical and clinical studies have shown that stem cell-based therapies hold
tremendous promise for the treatment of human disease. Mesenchymal stem cells (MSC) …

Human neurological disorders such as Parkinson's disease, Huntington's disease,
amyotrophic lateral sclerosis (ALS), Alzheimer's disease, multiple sclerosis (MS), stroke, and …

As immune regulators, cytokines serve critical role as signaling molecules in response to
danger, tissue damage, or injury. Importantly, due to their vital role in immunological …

Glioblastoma (GBM) is an aggressive central nervous system cancer with a dismal
prognosis. The standard of care involves surgical resection followed by radiotherapy and …

The poor prognosis for patients with aggressive or metastatic tumors and the toxic side
effects of currently available treatments necessitate the development of more effective tumor …