Challenges in developing Geroscience trials

Y Rolland, F Sierra, L Ferrucci, N Barzilai… - Nature …, 2023 - nature.com
Geroscience is becoming a major hope for preventing age-related diseases and loss of
function by targeting biological mechanisms of aging. This unprecedented paradigm shift …

Defining and assessing intrinsic capacity in older people: a systematic review and a proposed scoring system

S Lopez-Ortiz, S Lista, S Penin-Grandes… - Ageing Research …, 2022 - Elsevier
Abstract Introduction The World Health Organization has introduced the term 'intrinsic
capacity'(IC) as a marker of healthy ageing. However, controversy exists on the definition …

Implementation of the WHO integrated care for older people (ICOPE) programme in clinical practice: a prospective study

N Tavassoli, P de Souto Barreto, C Berbon… - The Lancet Healthy …, 2022 - thelancet.com
Background The INSPIRE integrated care for older people (ICOPE)-CARE programme is a
public health programme implementing the ICOPE health-care pathway in clinical practice …

Intrinsic capacity of older people in the community using WHO Integrated Care for Older People (ICOPE) framework: a cross-sectional study

AYM Leung, JJ Su, ESH Lee, JTS Fung, A Molassiotis - BMC geriatrics, 2022 - Springer
Abstract Background The World Health Organization (WHO) published the Integrated Care
for Older People (ICOPE) framework to guide assessing and promoting intrinsic capacity of …

[HTML][HTML] Intrinsic capacity in older adults: recent advances

Y Zhou, L Ma - Aging and disease, 2022 - ncbi.nlm.nih.gov
The global increase in the aging population is expected to result in a shift from disease-
centered to function-centered approaches in response to intensive aging. Thus, the World …

[HTML][HTML] Resilience and successful aging

I Aprahamian, J Woo, B Vellas, JE Morley - The Journal of nutrition, health …, 2022 - Elsevier
Resilience as one of the pillars of successful aging has received increasing attention from
the scientific community in recent years and has become even more important post-Covid …

The World Health Organization (WHO) integrated Care for Older People (ICOPE) framework: a narrative review on its adoption worldwide and lessons learnt

G Sum, LK Lau, KA Jabbar, P Lun, PP George… - International Journal of …, 2022 - mdpi.com
The World Health Organization (WHO) recently published guidelines on the implementation
of a new Integrated Care for Older People (ICOPE) framework in 2017–2019. It is an …

Real-life intrinsic capacity screening data from the ICOPE-Care program

P de Souto Barreto, E Gonzalez-Bautista… - Nature Aging, 2024 - nature.com
Abstract The Integrated Care for Older People (ICOPE) program is a healthcare pathway that
uses a screening test for intrinsic capacity (IC) as its entry point. However, real-life data …

Appetite loss and anorexia of aging in clinical care: an ICFSR task force report

P de Souto Barreto, M Cesari, JE Morley… - The Journal of frailty & …, 2022 - Springer
Appetite loss/anorexia of aging is a highly prevalent and burdensome geriatric syndrome
that strongly impairs the quality of life of older adults. Loss of appetite is associated with …

Exploring the natural history of intrinsic capacity impairments: longitudinal patterns in the 10/66 study

E Gonzalez-Bautista, JJ Llibre-Guerra, AL Sosa… - Age and …, 2023 - academic.oup.com
Background intrinsic capacity (IC) is a construct encompassing people's physical and mental
abilities. There is an implicit link amongst IC domains: cognition, locomotion, nutrition …