Microsensor systems for cell metabolism are essential tools for investigation and
standardization in cell culture. Electrochemical and optical read-out schemes dominate …

Coupled systems of in vitro microfabricated organs-on-a-chip containing small populations
of human cells are being developed to address the formidable pharmacological and …

Microphysiological systems (MPS), consisting of interacting organs-on-chips or tissue-
engineered, 3D organ constructs that use human cells, present an opportunity to bring new …

Microfluidics is becoming a technology of growing interest for building microphysiological
systems with integrated read-out functionalities. Here we present the integration of enzyme …

Technological advances in microfabrication techniques in combination with organotypic cell
and tissue models have enabled the realization of microphysiological systems capable of …

Real-time monitoring of changes to cellular bioenergetics can provide new insights into
mechanisms of action for disease and toxicity. This work describes the development of a …

Despite the significant progress in both scientific understanding and regulations, the safety
of agricultural pesticides continues to be called into question. The need for complementary …

Glial cells in their plurality pervade the human brain and impact on brain structure and
function. A principal component of the emerging glial doctrine is the hypothesis that …

Microphysiometry is a powerful technique to study metabolic parameters and detect
changes to external stimuli. However, applying this technique for automated label-free and …

Multianalyte microphysiometry is a powerful technique for studying cellular metabolic flux in
real time. Monitoring several analytes concurrently in a number of individual chambers …