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Neonatal encephalopathy due to a hypoxic-ischemic event is commonly associated with
cardiac dysfunction and acute pulmonary hypertension; both therapeutic hypothermia and …

Despite scientific advancement, hypoxemic respiratory failure remains a major challenge in
contemporary neonatal intensive care. Dysregulation of the pulmonary vascular bed and …

Objective To investigate the effects of persistent pulmonary hypertension (PPHN) and
oxygenation on outcome of neonates with neonatal encephalopathy (NE) treated with …

Neonates with neonatal encephalopathy (NE) often present with multi-organ dysfunction that
requires multidisciplinary specialized management. Care of the neonate with NE is thus …

Background Therapeutic hypothermia (TH) is the gold-standard treatment for moderate and
severe neonatal encephalopathy (NE). Care during TH has implications for long-term …

Originally approved by the US Food and Drug Administration (FDA) for its antihistamine
properties, clemastine can also promote white matter integrity and has shown promise in the …

Worldwide, hypoxic-ischemic encephalopathy (HIE) affects 2 million infants annually 1; it
presents clinically as neonatal encephalopathy (NE) is difficult to classify immediately after …

Rationale Preterm neonates needing rescue treatments with inotropes and/or inhaled nitric
oxide (iNO)(acute critical illnesses, ACIs) in neonatal intensive care units (NICUs) are at …

Background Compromised myocardial function and persistent elevated pulmonary vascular
resistance are common among neonates treated with therapeutic hypothermia (TH) for …