Niclosamide is an oral antihelminthic drug used to treat parasitic infections in millions of
people worldwide. However recent studies have indicated that niclosamide may have broad …

Mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that is part of mTOR
complex 1 (mTORC1), a master regulator that couples amino acid availability to cell growth …

The emergence of OpenAI's ChatGPT has put intense spotlight on Generative AI (Gen-AI)
systems and their possible impacts on Academic integrity. This paper provides an overview …

The rapid development of new anticancer drugs that are safe and effective is a common goal
shared by basic scientists, clinicians and patients. The current review discusses one such …

Recent reports indicate that hypoxia influences the circadian clock through the
transcriptional activities of hypoxia-inducible factors (HIFs) at clock genes. Unexpectedly, we …

Purpose: Enzalutamide, a second-generation antiandrogen, was recently approved for the
treatment of castration-resistant prostate cancer (CRPC) in patients who no longer respond …

The mechanistic target of rapamycin (mTOR) is a ubiquitous serine/threonine kinase, which
plays pivotal roles in integrating growth signals on a cellular level. To support proliferation …

Existing computational methods for drug repositioning either rely only on the gene
expression response of cell lines after treatment, or on drug-to-disease relationships …

Viruses use a limited set of host pathways for infection. These pathways represent bona fide
antiviral targets with low likelihood of viral resistance. We identified the salicylanilide …

Drug repositioning refers to the concept of discovering novel clinical benefits of drugs that
are already known for use treating other diseases. The advantages of this are that several …