The uptake of calcium into and extrusion of calcium from the mitochondrial matrix is a
fundamental biological process that has critical effects on cellular metabolism, signaling …

Mitochondrial Ca 2+ regulation is crucial for bioenergetics and cellular signaling. The
mechanisms controlling mitochondrial calcium homeostasis have been recently unraveled …

Glucagon's ability to increase energy expenditure has been known for more than 60 years,
yet the mechanisms underlining glucagon's thermogenic effect still remain largely elusive …

Background Bipolar disorder phenomenologically is a biphasic disorder of energy
availability; increased in mania and decreased in depression. In consort, there is …

Calcium signalling is fundamental to the function of the nervous system, in association with
changes in ionic gradients across the membrane. Although restoring ionic gradients is …

To examine the roles of mitochondrial calcium Ca 2+([Ca 2+] mt) and cytosolic Ca 2+([Ca
2+] cyt) in the regulation of hepatic mitochondrial fat oxidation, we studied a liver-specific …

Ca 2+ flux across the inner mitochondrial membrane (IMM) regulates cellular bioenergetics,
intra-cellular cytoplasmic Ca 2+ signals, and various cell death pathways. Ca 2+ entry into …

Emerging findings suggest that two lineages of mitochondrial Ca2+ uptake participate
during active and resting states: 1) the major eukaryotic membrane potential–dependent …

Background & Aims The cause of hepatic failure in the terminal stages of chronic injury is
unknown. Cellular metabolic adaptations in response to the microenvironment have been …

Glutamate elicits Ca 2+ signals and workloads that regulate neuronal fate both in
physiological and pathological circumstances. Oxidative phosphorylation is required in …