Dynamic regulation of mRNA translation initiation and elongation is essential for the survival
and function of neural cells. Global reductions in translation initiation resulting from …

Errors during mRNA translation can lead to a reduction in the levels of functional proteins
and an increase in deleterious molecules. Advances in next-generation sequencing have …

In neurodegenerative diseases, including pathologies with well-known causative alleles,
genetic factors that modify severity or age of onset are not entirely understood. We recently …

Whether errors in protein synthesis play a role in aging has been a subject of intense
debate. It has been suggested that rare mistakes in protein synthesis in young organisms …

Protein synthesis is an energetically costly cellular activity. It is therefore important that the
process of mRNA translation remains in excellent synchrony with cellular metabolism and its …

Mycobacterium abscessus is the most common rapidly growing non-tuberculous
mycobacteria to cause pulmonary disease in patients with impaired lung function such as …

Although regulation of translation fidelity is an essential process 1–7, diverse organisms and
organelles have differing requirements of translational accuracy 8–15, and errors in gene …

High fidelity tRNA aminoacylation by aminoacyl-tRNA synthetases is essential for cell
viability. ProXp-ala is a trans-editing protein that is present in all three domains of life and is …

Accurate pairing of amino acids and tRNAs is a prerequisite for faithful translation of genetic
information during protein biosynthesis. Here we present the effects of proteome-wide …

As the central dogma of molecular biology, genetic information flows from DNA through
transcription into RNA followed by translation of the message into protein by transfer RNAs …