Chitosan and its derivatives as polymeric anti-viral therapeutics and potential anti-SARS-CoV-2 nanomedicine

RSL Tan, P Hassandarvish, CF Chee, LW Chan… - Carbohydrate …, 2022 - Elsevier
The coronavirus pandemic, COVID-19 has a global impact on the lives and livelihoods of
people. It is characterized by a widespread infection by the severe acute respiratory …

Antiviral strategies against human metapneumovirus: Targeting the fusion protein

A Van Den Bergh, B Bailly, P Guillon, M von Itzstein… - Antiviral Research, 2022 - Elsevier
Human metapneumoviruses have emerged in the past decades as an important global
pathogen that causes severe upper and lower respiratory tract infections. Children under the …

Curcumin-poly (sodium 4-styrenesulfonate) conjugates as potent Zika virus entry inhibitors

M Obłoza, A Milewska, P Botwina… - … Applied Materials & …, 2024 - ACS Publications
Curcumin, a natural product with recognized antiviral properties, is limited in its application
largely due to its poor solubility. This study presents the synthesis of water-soluble curcumin …

Antivirals against animal viruses

TG Villa, L Feijoo-Siota, JLR Rama… - Biochemical Pharmacology, 2017 - Elsevier
Antivirals are compounds used since the 1960s that can interfere with viral development.
Some of these antivirals can be isolated from a variety of sources, such as animals, plants …

Berberine hampers influenza a replication through inhibition of MAPK/ERK pathway

P Botwina, K Owczarek, Z Rajfur, M Ochman, M Urlik… - Viruses, 2020 - mdpi.com
Background: Berberine (BBR) is an isoquinoline alkaloid which exhibits a variety of
biological and therapeutic properties, and has been reported by some to block replication of …

[HTML][HTML] Reversible rearrangement of the cellular cytoskeleton: A key to the broad-spectrum antiviral activity of novel amphiphilic polymers

A Dabrowska, P Botwina, E Barreto-Duran… - Materials Today Bio, 2023 - Elsevier
The battle against emerging viral infections has been uneven, as there is currently no broad-
spectrum drug available to contain the spread of novel pathogens throughout the …

Synthetic sulfonated derivatives of poly (allylamine hydrochloride) as inhibitors of human metapneumovirus

J Ciejka, P Botwina, M Nowakowska, K Szczubiałka… - PLoS …, 2019 - journals.plos.org
Human metapneumovirus (hMPV) is a widely distributed pathogen responsible for acute
upper and lower respiratory infections of varying severity. Previously, we reported that N …

Progress in Treatment and Diagnostics of Infectious Disease with Polymers

S Patra, D Pareek, PS Gupta, K Wasnik… - ACS Infectious …, 2024 - ACS Publications
In this era of advanced technology and innovation, infectious diseases still cause significant
morbidity and mortality, which need to be addressed. Despite overwhelming success in the …

Tuning the surface properties of poly (allylamine hydrochloride)-based multilayer films

J Ciejka, M Grzybala, A Gut, M Szuwarzynski, K Pyrc… - Materials, 2021 - mdpi.com
The layer-by-layer (LbL) method of polyelectrolyte multilayer (PEM) fabrication is extremely
versatile. It allows using a pair of any oppositely charged polyelectrolytes. Nevertheless, it …

A unique class of lignin derivatives displays broad anti-HIV activity by interacting with the viral envelope

M Oeyen, S Noppen, E Vanhulle, S Claes, BO Myrvold… - Virus research, 2019 - Elsevier
Abstract In Gordts et al.(2015), we have shown that lignosulfonic acid, a commercially
available lignin derivative, possesses broad antiviral activity against human …