Abstract The amphetamine derivative (±)-3, 4-methylenedioxymethamphetamine (MDMA,
ecstasy) is a popular recreational drug among young people, particularly those involved in …

Purinergic neurotransmission, involving release of ATP as an efferent neurotransmitter was
first proposed in 1972. Later, ATP was recognised as a cotransmitter in peripheral nerves …

Since high-affinity adenosine A2 receptors (A2a) are localized exclusively in dopamine-rich
regions in the central nervous system and mediate inhibition of locomotor activity, we have …

A cDNA fragment homologous to other G protein-coupled receptors was isolated from rat
brain using the PCR method and demonstrated to be abundantly expressed in striatum …

It is well known that the nucleoside adenosine exerts a modulatory influence in the central
nervous system by activating G protein coupled receptors. Adenosine A2A receptors, the …

In the 10 years since Daly reviewed1 the potentialof adenosine receptors as drug targets,
considerable advances have been made in the area of purinergic receptor related research …

Signalling in the CNS depends on a complex interplay between multiple transmitters and
their receptors. but also on the presence of local, nontransmitter factors. In this brief overview …

Pharmacotherapy of schizophrenia based on the dopamine hypothesis remains
unsatisfactory for the negative and cognitive symptoms of the disease. Enhancing N-methyl …

The locomotor stimulatory effects induced by caffeine (1, 3, 7-trimethylxanthine) in rodents
have been attributed to antagonism of adenosine A 1 and A 2A receptors. Little is known …

In the pursuit of improved treatments for Parkinson's disease (PD), the adenosine A2A
receptor has emerged as an attractive nondopaminergic target. Based on the compelling …