Detection of double-stranded RNAs (dsRNAs) is a central mechanism of innate immune
defense in many organisms. We here discuss several families of dsRNA-binding proteins …

Since the discovery of interferons (IFNs), considerable progress has been made in
describing the nature of the cytokines themselves, the signalling components that direct the …

Many RNA-binding proteins have modular structures and are composed of multiple repeats
of just a few basic domains that are arranged in various ways to satisfy their diverse …

The effects of interferons (IFNs) are mediated through the induction of around 2,000 IFN-
stimulated gene (ISG) products. However, the majority of these ISGs do not directly instigate …

Protein kinase R (PKR) is a central component of the interferon antiviral defense pathway.
Upon binding double-stranded RNA (dsRNA), PKR undergoes autophosphorylation …

The double-stranded (ds) RNA-activated protein kinase, PKR, has a key role in the innate
immunity response to viral infection in higher eukaryotes. PKR contains an N-terminal …

Translation initiation factors are over-expressed and/or activated in many human cancers
and may contribute to their genesis and/or progression. Removal of physiologic restraints on …

The interferon-inducible protein kinase R (PKR) is a key component of host innate immunity
that restricts viral replication and propagation. As one of the four eIF2α kinases that sense …

Adar null mutant mouse embryos die with aberrant double-stranded RNA (dsRNA)-driven
interferon induction, and Adar Mavs double mutants, in which interferon induction is …

Protein kinase R (PKR) functions in a plethora of cellular processes, including viral and
cellular stress responses, by phosphorylating the translation initiation factor eIF2α. The …