Infections are a major threat to human reproductive health, and infections in pregnancy can
cause prematurity or stillbirth, or can be vertically transmitted to the fetus leading to …

In brief The syndrome of preterm labor comprises multiple established and novel etiologies.
This review summarizes the distinct immune mechanisms implicated in preterm labor and …

The maternal-fetal interface undergoes dynamic changes to allow the fetus to grow and
develop in the uterus, despite being recognized by the maternal immune cells. Within the …

Physiological and molecular processes initiated during implantation for pregnancy success
are complex but highly organized. This review primarily highlights adverse ripple effects …

More than 135 million births occur each year; yet, the molecular underpinnings of human
parturition in gestational tissues, and in particular the placenta, are still poorly understood …

The immune cells that reside at the interface between the placenta and uterus are thought to
play many important roles in pregnancy. Recent work has revealed that the composition and …

Labor resembles an inflammatory response that includes secretion of cytokines/chemokines
by resident and infiltrating immune cells into reproductive tissues and the maternal/fetal …

Preterm birth is the leading cause of neonatal morbidity and mortality. Although the
underlying causes of pregnancy-associated complication are numerous, it is well …

Macrophages are a subset of mononuclear phagocytes of the innate immune system with
high plasticity and heterogeneity. At the maternal–fetal interface, macrophages are present …

Progress in our understanding of the role of the maternal immune system during healthy
pregnancy will help us better understand the role of the immune system in adverse …