The aging process worsens the human body functions at multiple levels, thus causing its
gradual decrease to resist stress, damage, and disease. Besides changes in gene …

Accumulating evidence indicates that intratumoral heterogeneity contributes to the
development of resistance to anticancer therapeutics. Fibroblasts, which are components of …

Many studies support a crucial role for oxidative & nitrosative stress (O&NS) in the
pathophysiology of unipolar and bipolar depression. These disorders are characterized inter …

Convincing concepts of redox control of gene transcription have been worked out for
prokaryotes and lower eukaryotes, whereas the knowledge on complex mammalian systems …

Cellular stress elicited by the toxic metal Cd 2+ does not coerce the cell into committing to
die from the onset. Rather, detoxification and adaptive processes are triggered concurrently …

Peroxisome‐proliferator activator receptor γ (PPARγ) is a nuclear receptor of central
importance in energy homeostasis and inflammation. Recent experimental pieces of …

Oxidative stress is related to ageing and degenerative diseases, including cancer. However,
a moderate amount of reactive oxygen species (ROS) is required for the regulation of …

Obesity has been proposed as an energy balance disorder in which the expansion of
adipose tissue (AT) leads to unfavorable health outcomes. Even though adiposity represents …

BACKGROUND: Trypanosomatids are early-diverging eukaryotes devoid of the major
disulfide reductases–glutathione reductase and thioredoxin reductase–that control thiol …

Tobacco smoking is an important public health issue recognized by the world health
organization as one of the most serious, preventable risk factors for developing a series of …