Large-scale neural recordings call for new insights to link brain and behavior

AE Urai, B Doiron, AM Leifer, AK Churchland - Nature neuroscience, 2022 - nature.com
Neuroscientists today can measure activity from more neurons than ever before, and are
facing the challenge of connecting these brain-wide neural recordings to computation and …

Why is everyone talking about brain state?

AS Greene, C Horien, D Barson, D Scheinost… - Trends in …, 2023 - cell.com
The rapid and coordinated propagation of neural activity across the brain provides the
foundation for complex behavior and cognition. Technical advances across neuroscience …

Norepinephrine links astrocytic activity to regulation of cortical state

ME Reitman, V Tse, X Mi, DD Willoughby… - Nature …, 2023 - nature.com
Cortical state, defined by population-level neuronal activity patterns, determines sensory
perception. While arousal-associated neuromodulators—including norepinephrine (NE) …

Distributed coding of choice, action and engagement across the mouse brain

NA Steinmetz, P Zatka-Haas, M Carandini, KD Harris - Nature, 2019 - nature.com
Vision, choice, action and behavioural engagement arise from neuronal activity that may be
distributed across brain regions. Here we delineate the spatial distribution of neurons …

Breathing coordinates cortico-hippocampal dynamics in mice during offline states

N Karalis, A Sirota - Nature communications, 2022 - nature.com
Network dynamics have been proposed as a mechanistic substrate for the information
transfer across cortical and hippocampal circuits. However, little is known about the …

Pupil size as a window on neural substrates of cognition

S Joshi, JI Gold - Trends in cognitive sciences, 2020 - cell.com
Cognitively driven pupil modulations reflect certain underlying brain functions. What do
these reflections tell us? Here, we review findings that have identified key roles for three …

Over and above frequency: Gamma oscillations as units of neural circuit operations

A Fernandez-Ruiz, A Sirota, V Lopes-dos-Santos… - Neuron, 2023 - cell.com
Summary Gamma oscillations (∼ 30–150 Hz) are widespread correlates of neural circuit
functions. These network activity patterns have been described across multiple animal …

Spontaneous behaviors drive multidimensional, brainwide activity

C Stringer, M Pachitariu, N Steinmetz, CB Reddy… - Science, 2019 - science.org
INTRODUCTION In the absence of sensory inputs, the brain produces structured patterns of
activity, which can be as large as or larger than sensory-driven activity. Ongoing activity …

Predictive processing: a canonical cortical computation

GB Keller, TD Mrsic-Flogel - Neuron, 2018 - cell.com
This perspective describes predictive processing as a computational framework for
understanding cortical function in the context of emerging evidence, with a focus on sensory …

Spatiotemporally heterogeneous coordination of cholinergic and neocortical activity

S Lohani, AH Moberly, H Benisty, B Landa, M Jing… - Nature …, 2022 - nature.com
Variation in an animal's behavioral state is linked to fluctuations in brain activity and
cognitive ability. In the neocortex, state-dependent circuit dynamics may reflect …