Abstract Structure‐based ligand design in medicinal chemistry and crop protection relies on
the identification and quantification of weak noncovalent interactions and understanding the …

Traditional descriptions of the hydrophobic effect on the basis of entropic arguments or the
calculation of solvent‐occupied surfaces must be questioned in view of new results obtained …

The cyclodextrin (CD)-based supramolecular nanomedicines have attracted growing
interest because of their superior characteristics, including desirable biocompatibility, low …

The world is made up of fundamental elements, ions and molecules that continuously
interact with each other through a series of chemical reactions. Thus, it is important to have a …

The mechanism (or mechanisms) of enthalpy–entropy (H/S) compensation in protein–ligand
binding remains controversial, and there are still no predictive models (theoretical or …

In life science, water is the ubiquitous solvent, sometimes even called the “matrix of life”.
There is increasing experimental and theoretical evidence that solvation water is not a …

Biomolecular recognition can be stubborn; changes in the structures of associating
molecules, or the environments in which they associate, often yield compensating changes …

As Lewis acids, boronic acids can bind with 1, 2-or 1, 3-diols in aqueous solution reversibly
and covalently to form five or six cyclic esters, thus resulting in significant fluorescence …

The value of thoroughly understanding the thermodynamics specific to a drug
discovery/design study is well known. Over the past decade, the crucial roles of water …

Terahertz (THz) spectroscopy has turned out to be a powerful tool which is able to shed new
light on the role of water in biomolecular processes. The low frequency spectrum of the …