Two decades of Martini: Better beads, broader scope

SJ Marrink, L Monticelli, MN Melo… - Wiley …, 2023 - Wiley Online Library
The Martini model, a coarse‐grained force field for molecular dynamics simulations, has
been around for nearly two decades. Originally developed for lipid‐based systems by the …

Nanodiscs: a versatile nanocarrier platform for cancer diagnosis and treatment

J Bariwal, H Ma, GA Altenberg, H Liang - Chemical Society Reviews, 2022 - pubs.rsc.org
Cancer therapy is a significant challenge due to insufficient drug delivery to the cancer cells
and non-selective killing of healthy cells by most chemotherapy agents. Nano-formulations …

Lipid nanodiscs for high-resolution NMR studies of membrane proteins

U Günsel, F Hagn - Chemical Reviews, 2021 - ACS Publications
Membrane proteins (MPs) play essential roles in numerous cellular processes. Because
around 70% of the currently marketed drugs target MPs, a detailed understanding of their …

A molecular view of DNA flexibility

A Marin-Gonzalez, JG Vilhena, R Perez… - Quarterly Reviews of …, 2021 - cambridge.org
DNA dynamics can only be understood by taking into account its complex mechanical
behavior at different length scales. At the micrometer level, the mechanical properties of …

Recent advances in DNA origami-engineered nanomaterials and applications

P Zhan, A Peil, Q Jiang, D Wang, S Mousavi… - Chemical …, 2023 - ACS Publications
DNA nanotechnology is a unique field, where physics, chemistry, biology, mathematics,
engineering, and materials science can elegantly converge. Since the original proposal of …

Hydrophobic interactions between DNA duplexes and synthetic and biological membranes

SF Jones, H Joshi, SJ Terry, JR Burns… - Journal of the …, 2021 - ACS Publications
Equipping DNA with hydrophobic anchors enables targeted interaction with lipid bilayers for
applications in biophysics, cell biology, and synthetic biology. Understanding DNA …

Binding of DNA origami to lipids: maximizing yield and switching via strand displacement

JKD Singh, E Darley, P Ridone, JP Gaston… - Nucleic acids …, 2021 - academic.oup.com
Liposomes are widely used as synthetic analogues of cell membranes and for drug delivery.
Lipid-binding DNA nanostructures can modify the shape, porosity and reactivity of …

Engineering lipid membranes with programmable DNA nanostructures

Q Shen, MW Grome, Y Yang, C Lin - Advanced biosystems, 2020 - Wiley Online Library
Lipid and DNA are abundant biomolecules with critical functions in cells. The water‐
insoluble, amphipathic lipid molecules are best known for their roles in energy storage (eg …

Dynamic DNA nanostructures in biomedicine: Beauty, utility and limits

A Jahanban-Esfahlan, K Seidi, M Jaymand… - Journal of Controlled …, 2019 - Elsevier
DNA composite materials are at the forefront, especially for biomedical science, as they can
increase the efficacy and safety of current therapies and drug delivery systems. The …

[HTML][HTML] Travel light: Essential packing for membrane proteins with an active lifestyle

NT Johansen, FG Tidemand, MC Pedersen, L Arleth - Biochimie, 2023 - Elsevier
We review the considerable progress during the recent decade in the endeavours of
designing, optimising, and utilising carrier particle systems for structural and functional …