Does maternal low-dose cadmium exposure increase the risk of offspring to develop metabolic syndrome and/or type 2 diabetes?

S Saedi, SE Watson, JL Young, Y Tan, KA Wintergerst… - Life sciences, 2023 - Elsevier
Cadmium is a hazardous metal with multiple organ toxicity that causes great harm to human
health. Cadmium enters the human body through occupational exposure, diet, drinking …

Emerging links between cadmium exposure and insulin resistance: human, animal, and cell study data

A Buha, D Đukić-Ćosić, M Ćurčić, Z Bulat, B Antonijević… - Toxics, 2020 - mdpi.com
Recent research has helped clarify the role of cadmium (Cd) in various pathological states.
We have demonstrated Cd involvement in pancreatic cancer, as well as the bioaccumulation …

[HTML][HTML] Cadmium exposure impairs pancreatic β-cell function and exaggerates diabetes by disrupting lipid metabolism

H Hong, Y Xu, J Xu, J Zhang, Y Xi, H Pi, L Yang… - Environment …, 2021 - Elsevier
Cadmium is known as an environmental pollutant that contributes to pancreatic damage and
the pathogenesis of diabetes. However, less attention has been devoted to elucidating the …

Mechanisms of Rhizoma Coptidis against type 2 diabetes mellitus explored by network pharmacology combined with molecular docking and experimental validation

W An, Y Huang, S Chen, T Teng, Y Shi, Z Sun, Y Xu - Scientific Reports, 2021 - nature.com
This study systematically explored the underlying mechanism of Rhizoma Coptidis against
type 2 diabetes mellitus (T2DM) by using network pharmacology and molecular docking and …

The melatonin receptor agonist agomelatine protects against acute pancreatitis induced by cadmium by attenuating inflammation and oxidative stress and modulating …

RS Alruhaimi, EHM Hassanein, MK Abd El-Aziz… - International …, 2023 - Elsevier
Pancreatitis is a serious effect of the heavy metal cadmium (Cd) and inflammation and
oxidative stress (OS) are implicated in Cd-induced pancreatic injury. This study evaluated …

Association between heavy metals, metalloids and metabolic syndrome: new insights and approaches

AC Martins, B Ferrer, AA Tinkov, S Caito… - Toxics, 2023 - mdpi.com
Metabolic syndrome (MetS) is an important public health issue that affects millions of people
around the world and is growing to pandemic-like proportions. This syndrome is defined by …

[HTML][HTML] Cadmium exposure disturbs myocardial lipid signature and induces inflammation in C57BL/6J mice

X Lin, Y Xu, T Tong, J Zhang, H He, L Yang… - Ecotoxicology and …, 2023 - Elsevier
Cadmium is a highly ubiquitous environmental pollutant that poses a serious threat to
human health. In this study, we assessed the cardiotoxicity of Cd exposure and explored the …

Targeting pancreatic beta cell death in type 2 diabetes by polyphenols

A García-Aguilar, C Guillén - Frontiers in Endocrinology, 2022 - frontiersin.org
Diabetes is a very complex disease which is characterized by the appearance of insulin
resistance that is primarily compensated by an increase in pancreatic beta cell mass …

Methylmercury induces mitochondria-and endoplasmic reticulum stress-dependent pancreatic β-cell apoptosis via an oxidative stress-mediated JNK signaling …

CY Yang, SH Liu, CC Su, KM Fang, TY Yang… - International journal of …, 2022 - mdpi.com
Methylmercury (MeHg), a long-lasting organic pollutant, is known to induce cytotoxic effects
in mammalian cells. Epidemiological studies have suggested that environmental exposure …

[HTML][HTML] Association of urinary cadmium, circulating fatty acids, and risk of gestational diabetes mellitus: a nested case-control study in China

X Li, Y Huang, Y Xing, C Hu, W Zhang, Y Tang… - Environment …, 2020 - Elsevier
Background Previous studies have observed that cadmium (Cd) exposure of pregnant
women was associated with increased risk of gestational diabetes mellitus (GDM). However …