The recent boom in microfluidics and combinatorial indexing strategies, combined with low
sequencing costs, has empowered single-cell sequencing technology. Thousands—or even …

Advances in our understanding of molecular mechanisms of tumorigenesis have translated
into knowledge-based therapies directed against specific oncogenic signaling targets …

The ability of circulating tumor cells (CTCs) to form clusters has been linked to increased
metastatic potential. Yet biological features and vulnerabilities of CTC clusters remain …

To the Editor—In medicine, digital twin models use real-time data to adjust treatment,
monitor response and track lifestyle modifications. Similarly, cancer patient digital twins …

During cancer progression, tumor cells undergo molecular and phenotypic changes
collectively referred to as cellular plasticity. Such changes result from microenvironmental …

Individualizing patient treatment is a core objective of the medical field. Reaching this
objective has been elusive owing to the complex set of factors contributing to both disease …

Drug-tolerant persister (DTP) cell populations were originally discovered in antibiotic-
resistant bacterial biofilms. Similar populations with comparable features have since been …

Why do we get cancer mostly when we are old? According to current paradigms, the answer
is simple: mutations accumulate in our tissues throughout life, and some of these mutations …

Many effective drugs for metastatic and/or advanced-stage cancers have been developed
over the past decade, although the evolution of resistance remains the major barrier to …

With the burgeoning use of immune-based treatments for cancer, never has there been a
greater need to understand the tumour microenvironment within which immune cells …