High-intensity focused ultrasound: a review of mechanisms and clinical applications

VS Bachu, J Kedda, I Suk, JJ Green, B Tyler - Annals of biomedical …, 2021 - Springer
Abstract High Intensity Focused Ultrasound (HIFU) is an emerging and increasingly useful
modality in the treatment of cancer and other diseases. Although traditional use of …

Local hyperthermia combined with radiotherapy and-/or chemotherapy: Recent advances and promises for the future

NR Datta, SG Ordóñez, US Gaipl, MM Paulides… - Cancer treatment …, 2015 - Elsevier
Hyperthermia, one of the oldest forms of cancer treatment involves selective heating of tumor
tissues to temperatures ranging between 39 and 45° C. Recent developments based on the …

[HTML][HTML] Hyperthermia and smart drug delivery systems for solid tumor therapy

ALB Seynhaeve, M Amin, D Haemmerich… - Advanced Drug Delivery …, 2020 - Elsevier
Chemotherapy is a cornerstone of cancer therapy. Irrespective of the administered drug, it is
crucial that adequate drug amounts reach all cancer cells. To achieve this, drugs first need …

Pharmacological and physical vessel modulation strategies to improve EPR-mediated drug targeting to tumors

T Ojha, V Pathak, Y Shi, WE Hennink… - Advanced drug delivery …, 2017 - Elsevier
The performance of nanomedicine formulations depends on the Enhanced Permeability and
Retention (EPR) effect. Prototypic nanomedicine-based drug delivery systems, such as …

Safety and feasibility of ultrasound-triggered targeted drug delivery of doxorubicin from thermosensitive liposomes in liver tumours (TARDOX): a single-centre, open …

PC Lyon, MD Gray, C Mannaris, LK Folkes… - The Lancet …, 2018 - thelancet.com
Background Previous preclinical research has shown that extracorporeal devices can be
used to enhance the delivery and distribution of systemically administered anticancer drugs …

[HTML][HTML] Recent technological advancements in radiofrequency-andmicrowave-mediated hyperthermia for enhancing drug delivery

MM Paulides, HD Trefna, S Curto… - Advanced drug delivery …, 2020 - Elsevier
Hyperthermia therapy is a potent enhancer of chemotherapy and radiotherapy. In particular,
microwave (MW) and radiofrequency (RF) hyperthermia devices provide a variety of heating …

Image-guided ultrasound phased arrays are a disruptive technology for non-invasive therapy

K Hynynen, RM Jones - Physics in Medicine & Biology, 2016 - iopscience.iop.org
Focused ultrasound offers a non-invasive way of depositing acoustic energy deep into the
body, which can be harnessed for a broad spectrum of therapeutic purposes, including …

Challenges and pitfalls in the development of liposomal delivery systems for cancer therapy

SA Moosavian, V Bianconi, M Pirro… - Seminars in cancer …, 2021 - Elsevier
Despite considerable advances in the application of liposomal drug delivery systems in
cancer treatment, the clinical application of liposomal formulations has been limited by many …

Multifunctional nanostructured drug delivery carriers for cancer therapy: Multimodal imaging and ultrasound-induced drug release

MV Novoselova, SV German, TO Abakumova… - Colloids and Surfaces B …, 2021 - Elsevier
Abstract Development of multimodal systems for therapy and diagnosis of neoplastic
diseases is an unmet need in oncology. The possibility of simultaneous diagnostics …

Recent advances in ultrasound-triggered drug delivery through lipid-based nanomaterials

A Ahmadi, S Hosseini-Nami, Z Abed, J Beik… - Drug Discovery …, 2020 - Elsevier
Highlights•The side effects on healthy tissue are of drawbacks of cancer chemotherapy.•
Nanocarriers to transport of chemotherapeutics into the tumor are an ideal scenario.• …