ABSTRACT N‐glycosylation is an important post‐translational modification of proteins that
has been highly conserved during evolution and is found in Eukaryota, Bacteria and …

Cells face major changes in demand for and supply of inorganic phosphate (Pi). Pi is often a
limiting nutrient in the environment, particularly for plants and microorganisms. At the same …

Despite advances in precision medicine, the clinical prospects for patients with ovarian and
uterine cancers have not substantially improved. Here, we analyzed genome-scale CRISPR …

About half of the eukaryotic proteins bind biometals that participate in their structure and
functions in virtually all physiological processes, including glycosylation. After reviewing the …

The uncharacterized protein family 0016 (UPF0016) is a family of secondary ion transporters
implicated in calcium homeostasis and some diseases. More precisely, genetic variants of …

TMEM165 is a Golgi protein playing a crucial role in Mn 2+ transport, and whose mutations
in patients are known to cause Congenital Disorders of Glycosylation. Some of those …

The GDT1 family is broadly spread and highly conserved among living organisms. GDT1
members have functions in key processes like glycosylation in humans and yeasts and …

Protein glycosylation in the Golgi is a sequential process that requires proper distribution of
transmembrane glycosyltransferase enzymes in the appropriate Golgi compartments. Some …

Abstract The Uncharacterized Protein Family 0016 (UPF0016) gathers poorly studied
membrane proteins well conserved through evolution that possess one or two copies of the …

The gradual acidification of the secretory pathway is conserved and extremely important for
eukaryotic cells, but until now there was no pH sensor available to monitor the pH of the …