The Rho GTPases are a family of molecular switches that are critical regulators of signal
transduction pathways in eukaryotic cells. They are known principally for their role in …

With the amount of genetic information available, a lot of attention has focused on systems
biology, in particular biomolecular interactions. Considering the huge number of such …

An important signaling pathway to the actin cytoskeleton links the Rho family GTPase Cdc42
to the actin-nucleating Arp2/3 complex through N-WASP. Nevertheless, these previously …

Background Ideally, disease modifying therapies for Alzheimer disease (AD) will be applied
during the 'preclinical'stage (pathology present with cognition intact) before severe neuronal …

Essential to salmonellae pathogenesis is an export device called the type III secretion
system (TTSS), which mediates the transfer of bacterial effector proteins from the bacterial …

The Rho-ROCK pathway modulates the phosphorylation level of a variety of important
signaling proteins and is thereby involved in miscellaneous cellular processes including cell …

IpaH proteins are bacterium-specific E3 enzymes that function as type three secretion
system (T3SS) effectors in Salmonella, Shigella, and other Gram-negative bacteria. IpaH …

The Ras superfamily small G proteins are master regulators of a diverse range of cellular
processes and act via downstream effector molecules. The first structure of a small G protein …

The mammalian protein kinase N (PKN) family of Serine/Threonine kinases comprises three
isoforms, which are targets for Rho family GTPases. Small GTPases are major regulators of …

ABSTRACT The small GTPase, Cdc42, is a key regulator of actin dynamics, functioning to
connect multiple signals to actin polymerization through effector proteins of the Wiskott …